Dolabellane diterpenoids from Aglaia odorata

被引：33

作者：

Cai, Xiang-Hai ^{[1
]}

Wang, Yuan-Yuan ^{[1
]}

Zhao, Pei-Ji ^{[1
]}

Li, Yan ^{[1
]}

Luo, Xiao-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 8-9期

基金：

中国国家自然科学基金;

关键词：

Aglaia odorata; Meliaceae; Dolabellane diterpenoids; X-ray; Cytotoxicity; LIVERWORT ODONTOSCHISMA-DENUDATUM; METABOLISM-PROMOTING ACTIVITIES; DICTYOTA-DICHOTOMA; CONFORMATION; STEREOCHEMISTRY; CALIFORNICA; ALKALOIDS;

D O I：

10.1016/j.phytochem.2010.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dolabellane diterpenoids, (1R,3E,7E,10S,11S,12R)-dolabella-3,7-dien-10,18-diol (1), (1R,35,7E,115,12R)dolabella-4(16),7-dien-3,18-diol (2), (1R,7E,11S,12R)-18-hydroxydolabella-4(16),7-dien-3-one (3), (1R,3S,4S,7E,115,12R)-3,4-epoxydolabella-7-en-18-ol (4), and (1R,3R,7E,11S,12R)-dolabella-4(16),7,18-trien-3-ol (5), were obtained from the ornamental plant Aglaia odorata. Their structures were characterized on the basis of spectroscopic analyses and further confirmed by X-ray diffraction. Compounds 1 and 5 showed weak cytotoxicity against the human myeloid leukemia HL-60, hepatocellular carcinoma SMMC-7721. and lung cancer A-549 cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1020 / 1024

页数：5

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