Dolabellane diterpenoids from Aglaia odorata

被引：33
|
作者：
Cai, Xiang-Hai [1 ]
Wang, Yuan-Yuan [1 ]
Zhao, Pei-Ji [1 ]
Li, Yan [1 ]
Luo, Xiao-Dong [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
来源：
PHYTOCHEMISTRY | 2010年 / 71卷 / 8-9期
基金：
中国国家自然科学基金;
关键词：
Aglaia odorata; Meliaceae; Dolabellane diterpenoids; X-ray; Cytotoxicity; LIVERWORT ODONTOSCHISMA-DENUDATUM; METABOLISM-PROMOTING ACTIVITIES; DICTYOTA-DICHOTOMA; CONFORMATION; STEREOCHEMISTRY; CALIFORNICA; ALKALOIDS;
D O I：
10.1016/j.phytochem.2010.03.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dolabellane diterpenoids, (1R,3E,7E,10S,11S,12R)-dolabella-3,7-dien-10,18-diol (1), (1R,35,7E,115,12R)dolabella-4(16),7-dien-3,18-diol (2), (1R,7E,11S,12R)-18-hydroxydolabella-4(16),7-dien-3-one (3), (1R,3S,4S,7E,115,12R)-3,4-epoxydolabella-7-en-18-ol (4), and (1R,3R,7E,11S,12R)-dolabella-4(16),7,18-trien-3-ol (5), were obtained from the ornamental plant Aglaia odorata. Their structures were characterized on the basis of spectroscopic analyses and further confirmed by X-ray diffraction. Compounds 1 and 5 showed weak cytotoxicity against the human myeloid leukemia HL-60, hepatocellular carcinoma SMMC-7721. and lung cancer A-549 cells. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1020 / 1024
页数：5
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