Efficient Syntheses of (±)-Cherylline and Latifine Dimethyl Ether

被引：6
|
作者：
Kumar, A. Sanjeev [1 ]
Ghosh, Samir [1 ]
Soundararajan, R. [1 ]
Mehta, G. N. [2 ]
机构：
[1] Pfizer Ltd, Chem Res & Dev Dept, Mumbai, Maharashtra, India
[2] SVNIT, Chem Sect, Appl Sci & Humanities Dept, Surat, India
来源：
SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 11期
关键词：
Michael reaction; Pictet-Spengler cyclization; reduction; tetrahydroisoquinolines; (&/-)-CHERYLLINE; CHERYLLINE; (+/-)-LATIFINE;
D O I：
10.1080/00397910903109859
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise route for the syntheses of (+/-)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet-Spengler cyclization.
引用
收藏
页码：1588 / 1594
页数：7
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