Convenient synthesis of amaryllidaceae alkaloid, (+/-) latifine dimethyl ether

被引：2
|
作者：
Kumar, A. Sanjeev [2 ]
Ghosh, Samir [2 ]
Bhima, Kale [2 ]
Mehta, G. N. [1 ]
机构：
[1] SV Natl Inst Technol, Dept Appl Chem, Surat 395007, India
[2] Pfizer Ltd, Chem Res & Dev Dept, Bombay 400705, Maharashtra, India
来源：
JOURNAL OF CHEMICAL RESEARCH | 2009年 / 10期
关键词：
Grignard reaction; reduction; tetrahydroisoquinolines; Pictet-Spengler cyclisation; reductive N-methylation; EFFICIENT SYNTHESIS; CHERYLLINE; 4-ARYL-1,2,3,4-TETRAHYDROISOQUINOLINES; (&/-)-CHERYLLINE; (+/-)-CHERYLLINE; (+/-)-LATIFINE;
D O I：
10.3184/030823409X12523442871697
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A short route for the synthesis of (+/-) latifine dimethyl ether is reported. The key steps involved are Grignard reaction, conversion of alcohol to nitrile using trimethylsilyl cyanide, reduction of the nitrile intermediate followed by Pictet-Spengler cyclisation and reductive N-methylation in a single step to provide latifine dimethyl ether as a racemate.
引用
收藏
页码：635 / 637
页数：3
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