Convenient synthesis of amaryllidaceae alkaloid, (+/-) latifine dimethyl ether

被引：2

作者：

Kumar, A. Sanjeev ^{[2
]}

Ghosh, Samir ^{[2
]}

Bhima, Kale ^{[2
]}

Mehta, G. N. ^{[1
]}

机构：

[1] SV Natl Inst Technol, Dept Appl Chem, Surat 395007, India

[2] Pfizer Ltd, Chem Res & Dev Dept, Bombay 400705, Maharashtra, India

来源：

JOURNAL OF CHEMICAL RESEARCH | 2009年 / 10期

关键词：

Grignard reaction; reduction; tetrahydroisoquinolines; Pictet-Spengler cyclisation; reductive N-methylation; EFFICIENT SYNTHESIS; CHERYLLINE; 4-ARYL-1,2,3,4-TETRAHYDROISOQUINOLINES; (&/-)-CHERYLLINE; (+/-)-CHERYLLINE; (+/-)-LATIFINE;

D O I：

10.3184/030823409X12523442871697

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A short route for the synthesis of (+/-) latifine dimethyl ether is reported. The key steps involved are Grignard reaction, conversion of alcohol to nitrile using trimethylsilyl cyanide, reduction of the nitrile intermediate followed by Pictet-Spengler cyclisation and reductive N-methylation in a single step to provide latifine dimethyl ether as a racemate.

引用

页码：635 / 637

页数：3

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