Efficient Syntheses of (±)-Cherylline and Latifine Dimethyl Ether

被引：6

作者：

Kumar, A. Sanjeev ^{[1
]}

Ghosh, Samir ^{[1
]}

Soundararajan, R. ^{[1
]}

Mehta, G. N. ^{[2
]}

机构：

[1] Pfizer Ltd, Chem Res & Dev Dept, Mumbai, Maharashtra, India

[2] SVNIT, Chem Sect, Appl Sci & Humanities Dept, Surat, India

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 11期

关键词：

Michael reaction; Pictet-Spengler cyclization; reduction; tetrahydroisoquinolines; (&/-)-CHERYLLINE; CHERYLLINE; (+/-)-LATIFINE;

D O I：

10.1080/00397910903109859

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise route for the syntheses of (+/-)-cherylline and latifine dimethyl ether is reported. The key steps involved are Michael addition of veratrole with p-methoxy nitrostyrene (for cherylline), anisole with 2,3-dimethoxy nitrostyrene (for latifine), and reduction of nitro intermediate, followed by Pictet-Spengler cyclization.

引用

页码：1588 / 1594

页数：7

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