Methods and Challenges in Quantitative Imaging Biomarker Development

被引：69

作者：

Abramson, Richard G. ^{[1
]}

Burton, Kirsteen R. ^{[2
,3
]}

Yu, John-Paul J. ^{[4
]}

Scalzetti, Ernest M. ^{[5
]}

Yankee, Thomas E. ^{[6
]}

Rosenkrantz, Andrew B. ^{[7
]}

Mendiratta-Lala, Mishal ^{[8
]}

Barth, Brian J. ^{[9
]}

Ganeshan, Dhakshinamoorthy ^{[10
]}

Lenchik, Leon ^{[11
]}

Subramaniam, Rathan M. ^{[12
,13
]}

机构：

[1] Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN 37232 USA

[2] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada

[3] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[4] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[5] SUNY Upstate Med Univ, Dept Radiol, Syracuse, NY 13210 USA

[6] Vanderbilt Univ, Inst Imaging Sci, Nashville, TN 37232 USA

[7] NYU, Dept Radiol, Langone Med Ctr, New York, NY 10016 USA

[8] Henry Ford Hosp, Abdominal & Cross Sect Intervent Radiol, Detroit, MI 48202 USA

[9] Mayo Clin, Div Radiol Informat, Rochester, MN USA

[10] Univ Texas MD Anderson Canc Ctr, Dept Abdominal Imaging, Houston, TX 77030 USA

[11] Wake Forest Sch Med, Dept Radiol, Winston Salem, NC USA

[12] Johns Hopkins Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA

[13] Johns Hopkins Univ, Dept Hlth Policy & Management, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA

来源：

ACADEMIC RADIOLOGY | 2015年 / 22卷 / 01期

基金：

美国医疗保健研究与质量局; 美国国家卫生研究院;

关键词：

Radiology; quantitative imaging; biomarker development; CONTRAST-ENHANCED MRI; CLINICAL-TRIAL DESIGNS; TUMOR RESPONSE; BREAST-CANCER; MURINE MODEL; REPRODUCIBILITY; VALIDATION; RADIOLOGY; CHEMOTHERAPY; MICROPET;

D O I：

10.1016/j.acra.2014.09.001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Academic radiology is poised to play an important role in the development and implementation of quantitative imaging (QI) tools. This article, drafted by the-Association of University Radiologists Radiology Research Alliance Quantitative Imaging Task Force, reviews current issues in QI biomarker research. We discuss motivations for advancing QI, define key terms, present a framework for QI biomarker research, and outline challenges in QI biomarker development. We conclude by describing where QI research and development is currently taking place and discussing the paramount role of academic radiology in this rapidly evolving field.

引用

页码：25 / 32

页数：8

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