Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin

被引：71
|
作者：
Schick, B. A.
Laaksonen, R.
Frohlich, J. J.
Paiva, H.
Lehtimaki, T.
Humphries, K. H.
Cote, H. C. F. [1 ]
机构：
[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada
[2] Tampere Univ Hosp, Res Unit, FIN-33101 Tampere, Finland
[3] Tampere Univ Hosp, Dept Internal Med, FIN-33101 Tampere, Finland
[4] Tampere Univ Hosp, Dept Clin Chem, FIN-33101 Tampere, Finland
[5] Tampere Univ Hosp, Lab Atherosclerosis Genet, FIN-33101 Tampere, Finland
[6] Univ British Columbia, Dept Cardiol, Vancouver, BC V5Z 1M9, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 81卷 / 05期
关键词：
D O I：
10.1038/sj.clpt.6100124
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Statins are generally well tolerated, but can cause myopathy(1) and have been associated with mitochondrial abnormalities.(2-6) The aim of this study was to determine whether muscle mitochondrial DNA ( mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published(7) clinical trial of high-dose simvastatin or atorvastatin versus placebo.
引用
收藏
页码：650 / 653
页数：4
相关论文
共 50 条
  • [31] Effects of exercise on mitochondrial DNA content in skeletal muscle of patients with COPD
    Puente-Maestu, Luis
    Lazaro, Alberto
    Tejedor, Alberto
    Camano, Sonia
    Fuentes, Marta
    Cuervo, Miguel
    Olaiz Navarro, Beatriz
    Agusti, Alvar
    THORAX, 2011, 66 (02) : 121 - 127
  • [32] The effects of low-dose simvastatin and ezetimibe compared to high-dose simvastatin on postprandial lipids and endothelial function in patients with the metabolic syndrome
    Olijhoek, Jobien K.
    Hajer, Gideon R.
    Van der Graat, Yolanda
    Dallinga-Thie, Geesje M.
    Visseren, Frank L.
    CIRCULATION, 2006, 114 (18) : 880 - 880
  • [33] Early, empiric high-dose leucovorin rescue in lymphoma patients treated with sequential doses of high-dose methotrexate
    Barreto, Jason N.
    Peterson, Kristen T.
    Barreto, Erin F.
    Mara, Kristin C.
    Dierkhising, Ross A.
    Leung, Nelson
    Witzig, Thomas E.
    Thompson, Carrie A.
    SUPPORTIVE CARE IN CANCER, 2021, 29 (09) : 5293 - 5301
  • [34] Early, empiric high-dose leucovorin rescue in lymphoma patients treated with sequential doses of high-dose methotrexate
    Jason N. Barreto
    Kristen T. Peterson
    Erin F. Barreto
    Kristin C. Mara
    Ross A. Dierkhising
    Nelson Leung
    Thomas E. Witzig
    Carrie A. Thompson
    Supportive Care in Cancer, 2021, 29 : 5293 - 5301
  • [35] In Vivo Treatment of AML Patients with High-Dose Simvastatin Inhibits Geranylgeranylation In AML Cells
    van der Weide, Karen
    de Jonge-Peeters, Susan D. P. W. M.
    Huls, Gerwin A.
    Fehrmann, Rudolf S. N.
    Schuringa, Jan J.
    Kuipers, Folkert
    de Vries, Elisabeth G. E.
    Vellenga, Edo
    BLOOD, 2010, 116 (21) : 1344 - 1344
  • [36] RENAL TUBULAR FUNCTION IN PATIENTS TREATED WITH HIGH-DOSE CISPLATIN
    DAUGAARD, G
    ABILDGAARD, U
    HOLSTEINRATHLOU, NH
    BRUUNSHUUS, I
    BUCHER, D
    LEYSSAC, PP
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1988, 44 (02) : 164 - 172
  • [37] THYMIDINE REQUIREMENTS FOR THE RESCUE OF PATIENTS TREATED WITH HIGH-DOSE METHOTREXATE
    HOWELL, SB
    HERBST, K
    BOSS, GR
    FREI, E
    CANCER RESEARCH, 1980, 40 (06) : 1824 - 1829
  • [38] RENAL-INSUFFICIENCY IN PATIENTS TREATED WITH HIGH-DOSE METHOTREXATE
    MAICHE, AG
    LAPPALAINEN, K
    TEERENHOVI, L
    ACTA ONCOLOGICA, 1988, 27 (01) : 73 - 74
  • [39] Periodontal infection in cancer patients treated with high-dose chemotherapy
    Raber-Durlacher, JE
    Epstein, JB
    Raber, J
    van Dissel, JT
    van Winkelhoff, AJ
    Guiot, HFL
    van der Velden, U
    SUPPORTIVE CARE IN CANCER, 2002, 10 (06) : 466 - 473
  • [40] Elevated methemoglobin levels in patients treated with high-dose hydroxocobalamin
    Dyrud, Martinus
    Niu, Jianli
    Kohler, Lisa
    LABORATORY MEDICINE, 2024, 55 (01) : 50 - 55
12345