Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin

被引：71
|
作者：
Schick, B. A.
Laaksonen, R.
Frohlich, J. J.
Paiva, H.
Lehtimaki, T.
Humphries, K. H.
Cote, H. C. F. [1 ]
机构：
[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada
[2] Tampere Univ Hosp, Res Unit, FIN-33101 Tampere, Finland
[3] Tampere Univ Hosp, Dept Internal Med, FIN-33101 Tampere, Finland
[4] Tampere Univ Hosp, Dept Clin Chem, FIN-33101 Tampere, Finland
[5] Tampere Univ Hosp, Lab Atherosclerosis Genet, FIN-33101 Tampere, Finland
[6] Univ British Columbia, Dept Cardiol, Vancouver, BC V5Z 1M9, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 81卷 / 05期
关键词：
D O I：
10.1038/sj.clpt.6100124
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Statins are generally well tolerated, but can cause myopathy(1) and have been associated with mitochondrial abnormalities.(2-6) The aim of this study was to determine whether muscle mitochondrial DNA ( mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published(7) clinical trial of high-dose simvastatin or atorvastatin versus placebo.
引用
收藏
页码：650 / 653
页数：4
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