Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin

被引：71
|
作者：
Schick, B. A.
Laaksonen, R.
Frohlich, J. J.
Paiva, H.
Lehtimaki, T.
Humphries, K. H.
Cote, H. C. F. [1 ]
机构：
[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada
[2] Tampere Univ Hosp, Res Unit, FIN-33101 Tampere, Finland
[3] Tampere Univ Hosp, Dept Internal Med, FIN-33101 Tampere, Finland
[4] Tampere Univ Hosp, Dept Clin Chem, FIN-33101 Tampere, Finland
[5] Tampere Univ Hosp, Lab Atherosclerosis Genet, FIN-33101 Tampere, Finland
[6] Univ British Columbia, Dept Cardiol, Vancouver, BC V5Z 1M9, Canada
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 81卷 / 05期
关键词：
D O I：
10.1038/sj.clpt.6100124
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Statins are generally well tolerated, but can cause myopathy(1) and have been associated with mitochondrial abnormalities.(2-6) The aim of this study was to determine whether muscle mitochondrial DNA ( mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published(7) clinical trial of high-dose simvastatin or atorvastatin versus placebo.
引用
收藏
页码：650 / 653
页数：4
相关论文
共 50 条
  • [1] Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin
    Schick, B. A.
    Laaksonen, R.
    Frohlich, J. J.
    Paiva, H.
    Lehtimaki, T.
    Humphries, K. H.
    Cote, H. C.
    ATHEROSCLEROSIS SUPPLEMENTS, 2007, 8 (01) : 199 - 200
  • [2] Decreased skeletal muscle mitochondrial DNA in patients on high-dose simvastatin therapy
    Schick, Brian
    Côté, Hélène C.
    Laaksonen, Reijo
    Päivä, Hannu
    Lehtimäki, Terho
    Frohlich, Jiri
    CIRCULATION, 2006, 114 (18) : 899 - 899
  • [3] Increased incidence of myositis in patients treated with high-dose simvastatin
    Galper, JB
    AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (02): : 259 - 259
  • [4] Simvastatin Effects on Skeletal Muscle Relation to Decreased Mitochondrial Function and Glucose Intolerance
    Larsen, Steen
    Stride, Nis
    Hey-Mogensen, Martin
    Hansen, Christina N.
    Bang, Lia E.
    Bundgaard, Henning
    Nielsen, Lars B.
    Helge, Jorn W.
    Dela, Flemming
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (01) : 44 - 53
  • [5] Decreased skeletal muscle mitochondrial DNA in patients with statin-induced myopathy
    Stringer, Henry A. J.
    Sohi, Gurmeet K.
    Maguire, John A.
    Cote, Helene C. F.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2013, 325 (1-2) : 142 - 147
  • [6] High-dose simvastatin and rhabdomyolysis
    Wratchford, P
    Ponte, CD
    AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2003, 60 (07) : 698 - 700
  • [7] High-dose atorvastatin therapy progressively decreases skeletal muscle mitochondrial respiratory capacity in humans
    Ryan, Terence E.
    Torres, Maria J.
    Lin, Chien-Te
    Clark, Angela H.
    Brophy, Patricia M.
    Smith, Cheryl A.
    Smith, Cody D.
    Morris, E. Matthew
    Thyfault, John P.
    Neufer, P. Darrell
    JCI INSIGHT, 2024, 9 (04)
  • [8] Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
    Mogensen, Martin
    Sahlin, Kent
    Fernstrom, Maria
    Glintborg, Dorte
    Vind, Birgitte F.
    Beck-Nielsen, Henning
    Hojlund, Kurt
    DIABETES, 2007, 56 (06) : 1592 - 1599
  • [9] HIGH-DOSE METOCLOPRAMIDE IN CISPLATIN TREATED PATIENTS
    FRUSTACI, S
    TIRELLI, U
    TUMOLO, S
    VERONESI, A
    GALLIGIONI, E
    TROVO, M
    GRIGOLETTO, E
    CHEMIOTERAPIA, 1983, 2 (02): : 75 - 77
  • [10] HYPERTHYROXINEMIA IN PATIENTS TREATED WITH HIGH-DOSE PROPANOLOL
    COOPER, DS
    DANIELS, GH
    LADENSON, PW
    RIDGWAY, EC
    AMERICAN JOURNAL OF MEDICINE, 1982, 73 (06): : 867 - 871
12345