THE EFFECT OF PORCINE OREXIN A ON GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE PLASMA CONCENTRATIONS IN PIGS

被引：6
|
作者：
Papakonstantinou, P. [1 ]
Tziris, N. [1 ]
Kapoukranidou, D.
Gotzamani-Psarrakou, A. [2 ]
Tsonidis, C. H. R. [3 ]
Patsikas, M. N. [4 ]
Papazoglou, G. [4 ]
机构：
[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Surg Clin 3, GR-54006 Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Dept Psychol, Sch Med, GR-54006 Thessaloniki, Greece
[3] Aristotle Univ Thessaloniki, Dept Nucl Med, GR-54006 Thessaloniki, Greece
[4] Aristotle Univ Thessaloniki, Dept Clin Sci, Neurosurg Clin 2, GR-54006 Thessaloniki, Greece
来源：
EUROPEAN JOURNAL OF INFLAMMATION | 2010年 / 8卷 / 01期
关键词：
Orexin A; GIP; gastrointestinal (or gut) hormones; i.c.v injection; enteroinsular axis; brain-gut axis; NEURONS; RELEASE;
D O I：
10.1177/1721727X1000800103
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The orexigenic system was discovered in 1998. It consists of two neuropeptides, Orexin A and Orexin B. Researchers have focused more on Orexin A, since its intracerebroventricular injection into the lateral ventricle of the rat's brain causes an increase in the consumption of food. Besides, it seems that, apart from appetite, Orexin A regulates many other physiological functions with unknown regulatory and metabolic mechanisms. Orexin A is produced by a small group of neurons located in and around the lateral hypothalamic area. It has been known for decades that the latter is involved in regulating feeding in mammals. An intravenous injection of Orexin A causes changes in insulin and glucagon plasma concentrations in rats. In this study, we investigated the possible effects of the central administration of porcine Orexin A on glucose-dependent insulinotropic polypeptide plasma concentrations in pigs, and examined whether these changes are related to the possible effect of the neuropeptide on the enteroinsular axis.
引用
收藏
页码：15 / 22
页数：8
相关论文
共 50 条
  • [41] Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification
    Getty-Kaushik, Lisa
    Song, Diane H.
    Boylan, Michael O.
    Corkey, Barbara E.
    Wolfe, M. Michael
    OBESITY, 2006, 14 (07) : 1124 - 1131
  • [42] The "other" incretin - the therapeutic rediscovery of the glucose-dependent insulinotropic polypeptide
    Winkler, Gabor
    Kis, Janos Tibor
    Schandl, Laszlo
    ORVOSI HETILAP, 2023, 164 (06) : 210 - 218
  • [43] NMR and modelling studies of glucose-dependent insulinotropic polypeptide (GIP)
    Alana, I.
    Parker, J. C.
    Gault, V. A.
    O'Harte, F. P. M.
    Malthouse, J. P. G.
    Hewage, C. M.
    JOURNAL OF PEPTIDE SCIENCE, 2006, 12 : 185 - 185
  • [44] FEEDBACK-REGULATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE BY INSULIN
    CHEUNG, A
    PEDERSON, RA
    BRYERASH, M
    CLINICAL RESEARCH, 1994, 42 (01): : A20 - A20
  • [45] GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE AUGMENTATION OF INSULIN - PHYSIOLOGY OR PHARMACOLOGY
    SARSON, DL
    WOOD, SM
    KANSAL, PC
    BLOOM, SR
    DIABETES, 1984, 33 (04) : 389 - 393
  • [46] Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes
    McIntosh, Christopher H. S.
    Widenmaier, Scott
    Kim, Su-Jin
    JOURNAL OF DIABETES INVESTIGATION, 2012, 3 (02): : 96 - 106
  • [47] Glucose Intolerance and Reduced Proliferation of Pancreatic β-Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function
    Renner, Simone
    Fehlings, Christiane
    Herbach, Nadja
    Hofmann, Andreas
    von Waldthausen, Dagmar C.
    Kessler, Barbara
    Ulrichs, Karin
    Chodnevskaja, Irina
    Moskalenko, Vasiliy
    Amselgruber, Werner
    Goeke, Burkhard
    Pfeifer, Alexander
    Wanke, Ruediger
    Wolf, Eckhard
    DIABETES, 2010, 59 (05) : 1228 - 1238
  • [48] Gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide signaling in adipose tissue
    Yamane, Shunsuke
    Harada, Norio
    JOURNAL OF DIABETES INVESTIGATION, 2019, 10 (01) : 3 - 5
  • [49] Impaired incretin effect in transgenic pigs expressinga dominant negative receptor for glucose-dependent insulinotropic polypeptide in the pancreatic islets
    Renner, S.
    Kessler, B.
    Herbach, N.
    von Waldthausen, D. C.
    Wanke, R.
    Hofmann, A.
    Pfeifer, A.
    Wolf, E.
    REPRODUCTION FERTILITY AND DEVELOPMENT, 2008, 20 (01) : 82 - 82
  • [50] Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of β cells in transgenic pigs
    JunLin Cheng
    Ying Wang
    Zhengwei Zhang
    Yong Jin
    QianKun Li
    RongGen Want
    Yan Wang
    XiaoKang Li
    Qiang Xiong
    ManLing Zhang
    RongFeng Li
    YiFan Dai
    The Journal of Biomedical Research, 2015, 29 (06) : 512 - 514
12345