THE EFFECT OF PORCINE OREXIN A ON GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE PLASMA CONCENTRATIONS IN PIGS

被引：6

作者：

Papakonstantinou, P. ^{[1
]}

Tziris, N. ^{[1
]}

Kapoukranidou, D.

Gotzamani-Psarrakou, A. ^{[2
]}

Tsonidis, C. H. R. ^{[3
]}

Patsikas, M. N. ^{[4
]}

Papazoglou, G. ^{[4
]}

机构：

[1] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Surg Clin 3, GR-54006 Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Dept Psychol, Sch Med, GR-54006 Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Dept Nucl Med, GR-54006 Thessaloniki, Greece

[4] Aristotle Univ Thessaloniki, Dept Clin Sci, Neurosurg Clin 2, GR-54006 Thessaloniki, Greece

来源：

EUROPEAN JOURNAL OF INFLAMMATION | 2010年 / 8卷 / 01期

关键词：

Orexin A; GIP; gastrointestinal (or gut) hormones; i.c.v injection; enteroinsular axis; brain-gut axis; NEURONS; RELEASE;

D O I：

10.1177/1721727X1000800103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The orexigenic system was discovered in 1998. It consists of two neuropeptides, Orexin A and Orexin B. Researchers have focused more on Orexin A, since its intracerebroventricular injection into the lateral ventricle of the rat's brain causes an increase in the consumption of food. Besides, it seems that, apart from appetite, Orexin A regulates many other physiological functions with unknown regulatory and metabolic mechanisms. Orexin A is produced by a small group of neurons located in and around the lateral hypothalamic area. It has been known for decades that the latter is involved in regulating feeding in mammals. An intravenous injection of Orexin A causes changes in insulin and glucagon plasma concentrations in rats. In this study, we investigated the possible effects of the central administration of porcine Orexin A on glucose-dependent insulinotropic polypeptide plasma concentrations in pigs, and examined whether these changes are related to the possible effect of the neuropeptide on the enteroinsular axis.

引用

页码：15 / 22

页数：8

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