In Vitro Study of ISApl1-Mediated Mobilization of the Colistin Resistance Gene mcr-1

被引：4
|
作者：
Poirel, Laurent [1 ,2 ,3 ]
Kieffer, Nicolas [1 ,2 ,3 ]
Nordmann, Patrice [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Fribourg, Dept Med, Emerging Antibiot Resistance Unit, Med & Mol Microbiol, Fribourg, Switzerland
[2] Univ Fribourg, French INSERM European Unit, LEA IAME, Fribourg, Switzerland
[3] Swiss Natl Reference Ctr Emerging Antibiot Resist, Fribourg, Switzerland
[4] Univ Lausanne, Lausanne, Switzerland
[5] Univ Hosp Ctr, Lausanne, Switzerland
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 07期
关键词：
ISApl1; composite transposon; mcr-1; plasmid; polymyxins; transposition; ESCHERICHIA-COLI; TRANSPOSITION; PLASMID; SEQUENCE; SWITZERLAND; FEATURES;
D O I：
10.1128/AAC.00127-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to polymyxins. The mcr-1 gene is associated with insertion sequence ISApl1 (IS30 family). In vitro mobilization assays demonstrated the functionality of the composite transposon structure ISApl1-mcr-1-ISApl1. Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the mcr-1 gene by transposition.
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页数：5
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