In Vitro Study of ISApl1-Mediated Mobilization of the Colistin Resistance Gene mcr-1

被引：4

作者：

Poirel, Laurent ^{[1
,2
,3
]}

Kieffer, Nicolas ^{[1
,2
,3
]}

Nordmann, Patrice ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Fribourg, Dept Med, Emerging Antibiot Resistance Unit, Med & Mol Microbiol, Fribourg, Switzerland

[2] Univ Fribourg, French INSERM European Unit, LEA IAME, Fribourg, Switzerland

[3] Swiss Natl Reference Ctr Emerging Antibiot Resist, Fribourg, Switzerland

[4] Univ Lausanne, Lausanne, Switzerland

[5] Univ Hosp Ctr, Lausanne, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 07期

关键词：

ISApl1; composite transposon; mcr-1; plasmid; polymyxins; transposition; ESCHERICHIA-COLI; TRANSPOSITION; PLASMID; SEQUENCE; SWITZERLAND; FEATURES;

D O I：

10.1128/AAC.00127-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to polymyxins. The mcr-1 gene is associated with insertion sequence ISApl1 (IS30 family). In vitro mobilization assays demonstrated the functionality of the composite transposon structure ISApl1-mcr-1-ISApl1. Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the mcr-1 gene by transposition.

引用

页数：5

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