Decay of coronavirus disease 2019 mRNA vaccine-induced immunity in people with HIV

被引：8
|
作者：
Woldemeskel, Bezawit A. [1 ]
Karaba, Andrew H. [1 ]
Garliss, Caroline C. [1 ]
Beck, Evan J. [2 ]
Aytenfisu, Tihitina Y. [1 ]
Johnston, Trevor S. [1 ]
Laeyendecker, Oliver [2 ]
Cox, Andrea L. [1 ]
Blankson, Joel N. [1 ]
机构：
[1] Johns Hopkins Med, Dept Med, Baltimore, MD USA
[2] NIAID, Div Intramural Res, NIH, Baltimore, MD USA
来源：
AIDS | 2022年 / 36卷 / 09期
关键词：
COVID-19; VACCINE; IMMUNOGENICITY; SARS-COV-2; INFECTION; SAFETY;
D O I：
10.1097/QAD.0000000000003263
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Current coronavirus disease 2019 (COVID-19) mRNA vaccines induce robust SARS-CoV-2-specific humoral and cellular responses in people with HIV (PWH). However, the rate of decay of effector immune responses has not been studied in these individuals. Here, we report a significant waning of antibody responses but persistent T-cell responses 6 months post vaccination in virally suppressed PWH with high CD4(+) T-cell counts. These responses are comparable with those seen in healthy donors.
引用
收藏
页码：1315 / 1317
页数：3
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