Decay of coronavirus disease 2019 mRNA vaccine-induced immunity in people with HIV

被引：8

作者：

Woldemeskel, Bezawit A. ^{[1
]}

Karaba, Andrew H. ^{[1
]}

Garliss, Caroline C. ^{[1
]}

Beck, Evan J. ^{[2
]}

Aytenfisu, Tihitina Y. ^{[1
]}

Johnston, Trevor S. ^{[1
]}

Laeyendecker, Oliver ^{[2
]}

Cox, Andrea L. ^{[1
]}

Blankson, Joel N. ^{[1
]}

机构：

[1] Johns Hopkins Med, Dept Med, Baltimore, MD USA

[2] NIAID, Div Intramural Res, NIH, Baltimore, MD USA

来源：

AIDS | 2022年 / 36卷 / 09期

关键词：

COVID-19; VACCINE; IMMUNOGENICITY; SARS-COV-2; INFECTION; SAFETY;

D O I：

10.1097/QAD.0000000000003263

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Current coronavirus disease 2019 (COVID-19) mRNA vaccines induce robust SARS-CoV-2-specific humoral and cellular responses in people with HIV (PWH). However, the rate of decay of effector immune responses has not been studied in these individuals. Here, we report a significant waning of antibody responses but persistent T-cell responses 6 months post vaccination in virally suppressed PWH with high CD4(+) T-cell counts. These responses are comparable with those seen in healthy donors.

引用

页码：1315 / 1317

页数：3

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