Role of Cigarette Smoke on Angiotensin-Converting Enzyme-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model
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作者:
Caruso, Massimo
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Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Caruso, Massimo
[1
,2
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Distefano, Alfio
[1
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Emma, Rosalia
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Univ Catania, Dept Biomed & Biotechnol Sci, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Emma, Rosalia
[1
]
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Di Rosa, Michelino
[1
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Carota, Giuseppe
[1
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Rust, Sonja
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机构:
Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Rust, Sonja
[2
]
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Polosa, Riccardo
[2
,3
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Zuccarello, Pietro
[4
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Ferrante, Margherita
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机构:
Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, Italy
Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Ferrante, Margherita
[2
,4
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Raciti, Giuseppina
[5
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Li Volti, Giovanni
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机构:
Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Li Volti, Giovanni
[1
,2
]
机构:
[1] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
[2] Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, Italy
[3] Univ Catania, Dept Clin & Expt Med, Catania, Italy
[4] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Catania, Italy
Prevalence studies of current smoking, among hospitalized COVID-19 patients, demonstrated an unexpectedly low prevalence among patients with COVID-19. The aim of the present study was to evaluate the effect of smoke from cigarettes on ACE-2 in bronchial epithelial cells. Normal bronchial epithelial cells (H292) were exposed to smoke by an air-liquid-interface (ALI) system and ACE-2 membrane protein expression was evaluated after 24 h from exposure. Our transcriptomics data analysis showed a significant selective reduction of membrane ACE-2 expression (about 25%) following smoking exposure. Interestingly, we observed a positive direct correlation between ACE-2 reduction and nicotine delivery. Furthermore, by stratifying GSE52237 as a function of ACE-2 gene expression levels, we highlighted 1,012 genes related to ACE-2 in smokers and 855 in non-smokers. Furthermore, we showed that 161 genes involved in the endocytosis process were highlighted using the online pathway tool KEGG. Finally, 11 genes were in common between the ACE-2 pathway in smokers and the genes regulated during endocytosis, while 12 genes with non-smokers. Interestingly, six in non-smokers and four genes in smokers were closely involved during the viral internalization process. Our data may offer a pharmaceutical role of nicotine as potential treatment option in COVID-19.
机构:
Hoseo Univ, Biochip Res Ctr, Asan 31499, South KoreaHoseo Univ, Biochip Res Ctr, Asan 31499, South Korea
Kim, Hee-Yun
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Kang, Ho-Geun
Kim, Hyung-Min
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Hoseo Univ, Biochip Res Ctr, Asan 31499, South Korea
Kyung Hee Univ, Coll Korean Med, Dept Pharmacol, Seoul 130701, South KoreaHoseo Univ, Biochip Res Ctr, Asan 31499, South Korea
Kim, Hyung-Min
Jeong, Hyun-Ja
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Hoseo Univ, Biochip Res Ctr, Asan 31499, South Korea
Hoseo Univ, Grad Sch, Dept Bioconvergence Syst, Asan 31499, South KoreaHoseo Univ, Biochip Res Ctr, Asan 31499, South Korea
机构:
Italian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Santoro, Massimo
Costabile, Francesca
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Inst Atmospher Sci & Climate Italian Natl Res Coun, Via Fosso Cavaliere, I-00133 Rome, Italy
NBFC Natl Biodivers Future Ctr, I-90133 Palermo, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Costabile, Francesca
Gualtieri, Maurizio
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Univ Milano Bicocca, Dept Earth & Environm Sci, Piazza Sci 1, I-20126 Milan, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Gualtieri, Maurizio
Rinaldi, Matteo
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NBFC Natl Biodivers Future Ctr, I-90133 Palermo, Italy
Inst Atmospher Sci & Climate Italian Natl Res Coun, Via Gobetti, I-40129 Bologna, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Rinaldi, Matteo
Paglione, Marco
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NBFC Natl Biodivers Future Ctr, I-90133 Palermo, Italy
Inst Atmospher Sci & Climate Italian Natl Res Coun, Via Gobetti, I-40129 Bologna, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Paglione, Marco
Busetto, Maurizio
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Inst Atmospher Sci & Climate Italian Natl Res Coun, Via Gobetti, I-40129 Bologna, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Busetto, Maurizio
Di Iulio, Gianluca
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Inst Atmospher Sci & Climate Italian Natl Res Coun, Via Fosso Cavaliere, I-00133 Rome, Italy
Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Via Eudossiana 18, I-00184 Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Di Iulio, Gianluca
Di Liberto, Luca
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Inst Atmospher Sci & Climate Italian Natl Res Coun, Via Fosso Cavaliere, I-00133 Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Di Liberto, Luca
Gherardi, Monica
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Italian WorkersCompensat Author INAIL, Dept Occupat & Environm Med Epidemiol & Hyg, I-00078 Monte Porzio Catone, Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Gherardi, Monica
Pelliccioni, Armando
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Italian WorkersCompensat Author INAIL, Dept Occupat & Environm Med Epidemiol & Hyg, I-00078 Monte Porzio Catone, Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Pelliccioni, Armando
Monti, Paolo
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Univ Roma La Sapienza, Dept Civil Bldg & Environm Engn, Via Eudossiana 18, I-00184 Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Monti, Paolo
Barbara, Benassi
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Italian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
Barbara, Benassi
Grollino, Maria Giuseppa
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Italian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, ItalyItalian Natl Agcy New Technol, Div Hlth Protect Technol, Energy & Sustainable Dev ENEA, I-00123 Rome, Italy
机构:
Seoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Lee, Kyoung-Hee
Jeong, Yunjeong
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Dongguk Univ, Div Pulm & Crit Care Med, Dept Internal Med, Ilsan Med Ctr, Goyang Si, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Jeong, Yunjeong
Kim, Ji Yeon
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Seoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Kim, Ji Yeon
Lee, Chang-Hoon
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Seoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
Lee, Chang-Hoon
Yoo, Chul-Gyu
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Seoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea
机构:
Univ S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Tabatabaian, Farnaz
Teng, Michael
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Univ S Florida, Dept Internal Med, Div Allergy & Immunol, Morsani Coll Med, Tampa, FL 33612 USA
Univ S Florida, Morsani Coll Med, Joy McCann Culverhouse Airway Dis Res Ctr, Tampa, FL USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Teng, Michael
Tran, Kim C.
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Univ S Florida, Dept Internal Med, Div Allergy & Immunol, Morsani Coll Med, Tampa, FL 33612 USA
Univ S Florida, Morsani Coll Med, Joy McCann Culverhouse Airway Dis Res Ctr, Tampa, FL USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Tran, Kim C.
Allen-Gipson, Diane
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Univ S Florida, Dept Pharm Sci, Tampa, FL USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Allen-Gipson, Diane
Tian, Zhi
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Univ S Florida, Dept Pharm Sci, Tampa, FL USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Tian, Zhi
Lockey, Richard F.
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Univ S Florida, Dept Internal Med, Div Allergy & Immunol, Morsani Coll Med, Tampa, FL 33612 USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Lockey, Richard F.
Xie, Yan
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机构:
Creighton Univ, Sch Med, Omaha, NE USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Xie, Yan
Tu, Yaping
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Creighton Univ, Sch Med, Omaha, NE USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA
Tu, Yaping
Casale, Thomas B.
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Univ S Florida, Morsani Coll Med, Tampa, FL USAUniv S Florida, All Childrens Hosp, Dept Pediat, Dept Allergy & Immunol, St Petersburg, FL 33701 USA