Role of Cigarette Smoke on Angiotensin-Converting Enzyme-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface Model
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作者:
Caruso, Massimo
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Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Caruso, Massimo
[1
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Distefano, Alfio
[1
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Emma, Rosalia
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Univ Catania, Dept Biomed & Biotechnol Sci, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Emma, Rosalia
[1
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Di Rosa, Michelino
[1
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Carota, Giuseppe
[1
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Rust, Sonja
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Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Rust, Sonja
[2
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Polosa, Riccardo
[2
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Zuccarello, Pietro
[4
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Ferrante, Margherita
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机构:
Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, Italy
Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Ferrante, Margherita
[2
,4
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Raciti, Giuseppina
[5
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Li Volti, Giovanni
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Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, ItalyUniv Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
Li Volti, Giovanni
[1
,2
]
机构:
[1] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy
[2] Univ Catania, Ctr Excellence Accelerat Harm Reduct CoEAHR, Catania, Italy
[3] Univ Catania, Dept Clin & Expt Med, Catania, Italy
[4] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Catania, Italy
Prevalence studies of current smoking, among hospitalized COVID-19 patients, demonstrated an unexpectedly low prevalence among patients with COVID-19. The aim of the present study was to evaluate the effect of smoke from cigarettes on ACE-2 in bronchial epithelial cells. Normal bronchial epithelial cells (H292) were exposed to smoke by an air-liquid-interface (ALI) system and ACE-2 membrane protein expression was evaluated after 24 h from exposure. Our transcriptomics data analysis showed a significant selective reduction of membrane ACE-2 expression (about 25%) following smoking exposure. Interestingly, we observed a positive direct correlation between ACE-2 reduction and nicotine delivery. Furthermore, by stratifying GSE52237 as a function of ACE-2 gene expression levels, we highlighted 1,012 genes related to ACE-2 in smokers and 855 in non-smokers. Furthermore, we showed that 161 genes involved in the endocytosis process were highlighted using the online pathway tool KEGG. Finally, 11 genes were in common between the ACE-2 pathway in smokers and the genes regulated during endocytosis, while 12 genes with non-smokers. Interestingly, six in non-smokers and four genes in smokers were closely involved during the viral internalization process. Our data may offer a pharmaceutical role of nicotine as potential treatment option in COVID-19.
机构:
Univ Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Campos, Mariana F.
Constant, Larissa E. C.
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Univ Fed Rio De Janeiro, Ctr Ciencias Saude, Lab Biotecnol & Bioengn Estrutural, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, RJ, Brazil
Univ Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Biotecnol Farmaceut, Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Constant, Larissa E. C.
Teixeira, Douglas E.
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Univ Fed Rio de Janeiro, Lab Pulm Investigat, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Teixeira, Douglas E.
Silva-Aguiar, Rodrigo P.
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Univ Fed Rio de Janeiro, Lab Pulm Investigat, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Silva-Aguiar, Rodrigo P.
Rocco, Patricia R. M.
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Univ Fed Rio De Janeiro, Ctr Ciencias Saude, Lab Invest Pulm, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Rocco, Patricia R. M.
Mohana-Borges, Ronaldo
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Univ Fed Rio De Janeiro, Ctr Ciencias Saude, Lab Biotecnol & Bioengn Estrutural, Inst Biofis Carlos Chagas Filho, Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Mohana-Borges, Ronaldo
Leitao, Gilda G.
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Univ Fed Rio De Janeiro, Ctr Ciencias Saude, Inst Pesquisa Prod Nat, Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Leitao, Gilda G.
Caruso-Neves, Celso
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Univ Fed Rio de Janeiro, Lab Pulm Investigat, Inst Biofis Carlos Chagas Filho, Ctr Ciencias Saude, BR-21949900 Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Caruso-Neves, Celso
Leitao, Suzana G.
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Univ Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
Leitao, Suzana G.
Allonso, Diego
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Univ Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Biotecnol Farmaceut, Rio De Janeiro, RJ, BrazilUniv Fed Rio De Janeiro, Fac Farm, Ctr Ciencias Saude, Dept Prod Nat & Alimentos,Lab Fitoquim & Farmacogn, Rio De Janeiro, RJ, Brazil
机构:
Fourth Mil Med Univ, Tangdu Hosp, Dept Respirat, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Respirat, Xian 710038, Peoples R China
Zhao Yilin
Nan Yandong
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Fourth Mil Med Univ, Tangdu Hosp, Dept Respirat, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Respirat, Xian 710038, Peoples R China
Nan Yandong
Jin Faguang
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Fourth Mil Med Univ, Tangdu Hosp, Dept Respirat, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Tangdu Hosp, Dept Respirat, Xian 710038, Peoples R China