In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci

被引：36

作者：

Giacometti, Andrea

Cirioni, Oscar

Riva, Alessandra

Kamysz, Wojciech

Silvestri, Carmela

Nadolski, Piotr

Della Vittoria, Agnese

Lukasiak, Jerzy

Scalise, Giorgio

机构：

[1] Osped Reg, Inst Infect Dis & Publ Hlth, I-60020 Ancona, Italy

[2] Univ Politecn Marche, Inst Infect Dis & Publ Hlth, Ancona, Italy

[3] Med Univ Gdansk, Fac Pharm, Gdansk, Poland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期

关键词：

FROGS LITORIA-AUREA; ANTIMICROBIAL PEPTIDES; RANIFORMIS; SKIN;

D O I：

10.1128/AAC.00666-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.

引用

页码：1494 / 1496

页数：3

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