In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci

被引：36
|
作者：
Giacometti, Andrea
Cirioni, Oscar
Riva, Alessandra
Kamysz, Wojciech
Silvestri, Carmela
Nadolski, Piotr
Della Vittoria, Agnese
Lukasiak, Jerzy
Scalise, Giorgio
机构：
[1] Osped Reg, Inst Infect Dis & Publ Hlth, I-60020 Ancona, Italy
[2] Univ Politecn Marche, Inst Infect Dis & Publ Hlth, Ancona, Italy
[3] Med Univ Gdansk, Fac Pharm, Gdansk, Poland
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期
关键词：
FROGS LITORIA-AUREA; ANTIMICROBIAL PEPTIDES; RANIFORMIS; SKIN;
D O I：
10.1128/AAC.00666-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.
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页码：1494 / 1496
页数：3
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