Synthesis and studies on antimicrobial, antiinflammatory and antiproliferative activities of heterocycles derived from 4-/5-/6-/7-nitro/5-fluoro/chloro/bromoindole-2-carbohydrazides

被引：0
|
作者：
Narayana, B. [1 ]
Ashalatha, B. V.
Raj, K. K. Vijaya
Sarojini, B. K. [2 ]
机构：
[1] Mangalore Univ, Dept Studies & Res Chem, Mangalagangothri 574199, Karnataka, India
[2] PA Coll Engn, Dept Chem, Mangalore 574153, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2009年 / 48卷 / 12期
关键词：
Synthesis; heterocycles; indoles; antimicrobial; anti-inflammatory; antiproliferative activity;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthesis and studies on antimicrobial, antinflammatory and antiproliferative activities of heterocycles derived from 4/5-/6-/7-nitro/5-fluoro/chloro/bromoindole-2-carbohydrazides are discussed. 4-/5-/6-/7-nitroindole-2-carbohydrazides and 5-fluoro/chloro/bromoindole-2-carbohydrazides on treatment with acetyl acetone in methanol have resulted in 2-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-4-/5-/6-/7-nitro-1H-indoles and 2-[(3,5-dimethyl-1H-pyrazol-1-yl)carbonyl]-5-fluoro/chloro/bromo-1H-indoles respectively. 4-/6-/7-nitroindole-2-carbohydrazides on treatment with CS2/KOH in methanol have yielded 5-(4-/6-/7-nitro-1H-indol-2-yl)-1,3,4- oxadiazole-2-thiol and with cyanogen bromide yielded 5-(4-/6-/7-nitro-1H- indol-2-yl)-1,3,4-oxadiazol-2-amine. Nitroindole-2-carbohydrazides are also treated with various aromatic carboxylic acids and triethyl orthoformate yielded 2-[5-(aryl)-1,3,4-oxadiazol-2-yl]-4-/5-/6-/7-nitro-1H-indoles and 4-/6- /7-nitro-2-(1,3,4-oxadiazol-2-yl)-1H-indoles, respectively. Structures of the newly synthesized compounds are characterized by analytical and spectral data.
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页码：1794 / 1805
页数：12
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