The effect of a formulation excipient on monoclonal antibody tryptophan oxidation

被引：0
|
作者：
Yang, Jessica [1 ]
Strahan, Alex [2 ]
Alavattam, Sreedhara [3 ]
Wang, Y. John [3 ]
Kabakoff, Bruce [1 ]
Salisbury, Cleo [1 ]
机构：
[1] Genentech Inc, Early Stage Pharmaceut Dev, San Francisco, CA 94080 USA
[2] Genentech Inc, Prot Analyt Chem, San Francisco, CA 94080 USA
[3] Genentech Inc, Late Stage Pharmaceut Dev, San Francisco, CA 94080 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 255卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
213
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Response of a Concentrated Monoclonal Antibody Formulation to High Shear
    Bee, Jared S.
    Stevenson, Jennifer L.
    Mehta, Bhavya
    Svitel, Juraj
    Pollastrini, Joey
    Platz, Robert
    Freund, Erwin
    Carpenter, John F.
    Randolph, Theodore W.
    BIOTECHNOLOGY AND BIOENGINEERING, 2009, 103 (05) : 936 - 943
  • [22] Formulation development of a monoclonal antibody - Linking structure to stability
    Li, L
    Luksha, N
    Kantor, A
    Warne, N
    PROTEIN SCIENCE, 2004, 13 : 237 - 237
  • [23] Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation
    Salinas, Branden A.
    Sathish, Hasige A.
    Bishop, Steven M.
    Harn, Nick
    Carpenter, John F.
    Randolph, Theodore W.
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (01) : 82 - 93
  • [24] PHOTOSENSITIZED OXIDATION OF TRYPTOPHAN - EFFECT ON LIVER AND BRAIN TRYPTOPHAN
    BHATIA, J
    RASSIN, DK
    MCADOO, DJ
    JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 1991, 15 (06) : 637 - 641
  • [25] Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations
    Andya J.D.
    Hsu C.C.
    Shire S.J.
    AAPS PharmSci, 5 (2): : XV - XVI
  • [26] Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations
    Andya, JD
    Hsu, CC
    Shire, SJ
    AAPS PHARMSCI, 2003, 5 (02):
  • [27] Stable High-Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient
    Klich, John H.
    Kasse, Catherine M.
    Mann, Joseph L.
    Huang, Yaoqi
    D'Aquino, Andrea, I
    Grosskopf, Abigail K.
    Baillet, Julie
    Fuller, Gerald G.
    Appel, Eric A.
    ADVANCED THERAPEUTICS, 2023, 6 (01)
  • [28] Effect of the Siliconization Method on Particle Generation in a Monoclonal Antibody Formulation in Pre-filled Syringes
    Gerhardt, Alana
    Nguyen, Bao H.
    Lewus, Rachael
    Carpenter, John F.
    Randolph, Theodore W.
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 104 (05) : 1601 - 1609
  • [29] Machine Learning Models of Antibody-Excipient Preferential Interactions for Use in Computational Formulation Design
    Cloutier, Theresa K.
    Sudrik, Chaitanya
    Mody, Neil
    Sathish, Hasige A.
    Trout, Bernhardt L.
    MOLECULAR PHARMACEUTICS, 2020, 17 (09) : 3589 - 3599
  • [30] The effect of formulation variables on protein stability and integrity of a model IgG4 monoclonal antibody and translation to formulation of a model ScFv
    Gourbatsi, Evdoxia
    Povey, Jane F.
    Smales, C. Mark
    BIOTECHNOLOGY LETTERS, 2018, 40 (01) : 33 - 46
12345