The copper-catalyzed selective monoalkylation of active methylene compounds with alkylsilyl peroxides

被引：14
|
作者：
Lv, Jiamin [1 ]
Xu, Weiping [1 ]
Lu, Hanbin [1 ]
Kato, Terumasa [1 ]
Liu, Yan [1 ]
Maruoka, Keiji [1 ,2 ]
机构：
[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China
[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 12期
基金：
中国国家自然科学基金;
关键词：
ALKYLATION;
D O I：
10.1039/d1ob00075f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method for a mild copper-catalyzed selective monoalkylation of active methylene compounds with various alkylsilyl peroxides has been developed. The reaction has a broad substrate scope and our mechanistic studies suggest the participation of radical species in this alkylation reaction.
引用
收藏
页码：2658 / 2662
页数：5
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