Copper-catalyzed oxidative cyclization of 2-(1H-pyrrol-1-yl)aniline and alkylsilyl peroxides: a route to pyrrolo[1,2-a]quinoxalines

被引：4
|
作者：
An, Zhenyu [1 ]
Miao, Man [1 ]
Sun, Fengkai [1 ]
Lan, Xiao-Bing [1 ]
Yu, Jian-Qiang [1 ]
Guo, Xiaoli [1 ]
Zhang, Jian [1 ,2 ]
机构：
[1] Ningxia Med Univ, Coll Pharm, Key Lab Protect Dev & Utilizat Med Resources Liupa, Yinchuan, Ningxia Hui Aut, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Med Chem & Bioinformat Ctr, Shanghai, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 12期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
EFFICIENT SYNTHESIS; C-C; ACID;
D O I：
10.1039/d3ob01934a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method was developed for the one-pot construction of pyrrolo[1,2-a]quinoxalines via a Cu(ii)-catalyzed domino reaction between 2-(1H-pyrrol-1-yl)anilines and alkylsilyl peroxides. This reaction proceeds through C-C bond cleavage and new C-C and C-N bond formation. A mechanistic study suggests that alkyl radical species participate in the cascade reaction.
引用
收藏
页码：2370 / 2374
页数：5
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