An efficient synthesis of thiazolo[3,2-a]pyrimidinones

被引：9
|
作者：
Ahmad, Nadia M. [1 ]
Jones, Keith [1 ]
机构：
[1] Inst Canc Res, Canc Res UK Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 25期
关键词：
4-QUINOLONES; ACCESS; ACID;
D O I：
10.1016/j.tetlet.2010.04.052
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of thiazolo[3,2-a]pyrimidinones was synthesised in a two-step procedure, using Eaton's reagent to effect cyclisation of 2-aminothiazoles. The use of relatively low temperatures, facile product isolation and short reaction times make this cyclisation procedure a particularly attractive option over more conventional methods. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：3263 / 3265
页数：3
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