Synthesis and antiviral activity of new benzothiadiazine dioxide derivatives

被引：13
|
作者：
Tait, A
Luppi, A
Cermelli, C
机构：
[1] Univ Modena, Dipartimento Sci Farmaceut, I-41100 Modena, Italy
[2] Univ Modena, Dipartimento Sci Igienistiche Microbiol & Biostat, I-41100 Modena, Italy
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 41卷 / 05期
关键词：
D O I：
10.1002/jhet.5570410516
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2,1,3- and 1,2,4-benzothiadiazine derivatives were synthesized by alkylation via Mitsunobu reaction and evaluated for their antiviral activity against ADV, HHV-6, Cox-B5 and H-CMV Most of them were active at micromolar level against one or more viral strains. All the molecules studied are poorly cytotoxic (maximum non toxic concentrations were > 25 muM), except one compound that presents a higher cytotoxicity (maximum non toxic concentration was 6 muM).
引用
收藏
页码：747 / 753
页数：7
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