Synthesis and antiviral activity of new benzothiadiazine dioxide derivatives

被引：13

作者：

Tait, A

Luppi, A

Cermelli, C

机构：

[1] Univ Modena, Dipartimento Sci Farmaceut, I-41100 Modena, Italy

[2] Univ Modena, Dipartimento Sci Igienistiche Microbiol & Biostat, I-41100 Modena, Italy

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 41卷 / 05期

关键词：

D O I：

10.1002/jhet.5570410516

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2,1,3- and 1,2,4-benzothiadiazine derivatives were synthesized by alkylation via Mitsunobu reaction and evaluated for their antiviral activity against ADV, HHV-6, Cox-B5 and H-CMV Most of them were active at micromolar level against one or more viral strains. All the molecules studied are poorly cytotoxic (maximum non toxic concentrations were > 25 muM), except one compound that presents a higher cytotoxicity (maximum non toxic concentration was 6 muM).

引用

页码：747 / 753

页数：7

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