Scale-up and safety evaluation of a Sandmeyer reaction

被引：43

作者：

Nielsen, MA ^{[1
]}

Nielsen, MK ^{[1
]}

Pittelkow, A ^{[1
]}

机构：

[1] H Lundbeck & Co AS, Chem Prod, DK-4500 Nykobing Sj, Denmark

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 06期

关键词：

D O I：

10.1021/op0498823

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A scale-up of a new process for the production of 2-chloro-5-trifluoromethyl-benzonitrile by a Sandmeyer reaction of 2-Chloro-5-trifluoromethylaniline with copper cyanide/sodium cyanide is described. To ensure a safe implementation, a safety evaluation of the process was carried out, which is described. in the following. The new process gives a better working environment and better productivity due to shorter reaction time.

引用

页码：1059 / 1064

页数：6

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