Scale-up and safety evaluation of a Sandmeyer reaction

被引：43

作者：

Nielsen, MA ^{[1
]}

Nielsen, MK ^{[1
]}

Pittelkow, A ^{[1
]}

机构：

[1] H Lundbeck & Co AS, Chem Prod, DK-4500 Nykobing Sj, Denmark

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 06期

关键词：

D O I：

10.1021/op0498823

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A scale-up of a new process for the production of 2-chloro-5-trifluoromethyl-benzonitrile by a Sandmeyer reaction of 2-Chloro-5-trifluoromethylaniline with copper cyanide/sodium cyanide is described. To ensure a safe implementation, a safety evaluation of the process was carried out, which is described. in the following. The new process gives a better working environment and better productivity due to shorter reaction time.

引用

页码：1059 / 1064

页数：6

共 50 条

[11] Process scale considerations in evaluation studies and scale-up
Walter, JK
Werz, W
Berthold, W
VIRAL SAFETY AND EVALUATION OF VIRAL CLEARANCE FROM BIOPHARMACEUTICAL PRODUCTS, 1996, 88 : 99 - 108
[12] Process Safety Evaluation and Scale-up of a Lactam Reduction with NaBH4 and TFA
Naka, Takashi
Ozawa, Hiroki
Toyama, Ken-ichi
Shirasaka, Tadashi
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2015, 19 (11) : 1747 - 1751
[13] Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction
Armstrong, Brittany M.
Behre, Taylor
Turnbull, Ben W. H.
Bishara, Daniel
Hartmanshenn, Clara
McCarthy, Erin
Whittington, Michael
Ji, Yining
Jenks, Anna
Desmond, Richard
Muzzio, Daniel J.
Corry, James
Zhao, Ralph
Kuhl, Nadine
Chung, Cheol K.
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023, 27 (04) : 763 - 774
[14] HAZARD EVALUATION AND SCALE-UP OF A COMPLEX-REACTION WITH THE AID OF KINETIC AND REACTOR MODELING
CHAKRABARTI, A
STEINER, EC
WERLING, CL
YOSHIMINE, M
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1984, 187 (APR): : 20 - CHAS
[15] APPLICATION OF CHEMICAL REACTION KINETICS IN PROCESS SCALE-UP
CORRIGAN, TE
DEAN, MJ
BRITISH CHEMICAL ENGINEERING, 1968, 13 (09): : 445 - &
[16] Industrial scale-up of countercurrent chromatography: Predictive scale-up
Sutherland, IA
Brown, L
Graham, AS
Guillon, GG
Hawes, D
Janaway, L
Whiteside, R
Wood, P
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2001, 39 (01) : 21 - 28
[17] Hazard Evaluation of Metal-Organic Framework Synthesis and Scale-up: A Laboratory Safety Perspective
Escobar-Hernandez, Harold U.
Shen, Ruiqing
Papadaki, Maria, I
Powell, Joshua A.
Zhou, Hong-Cai
Wang, Qingsheng
ACS CHEMICAL HEALTH & SAFETY, 2021, 28 (05) : 358 - 368
[18] Safety Assessments Supporting Scale-up of Chemistry Involving Hydrogen
Yang, Cuixian
Wang, Tao
Muzzio, Daniel J.
Van Cleaf, Stephen
Phillips, Eric M.
Fine, Adam J.
Vickery, Thomas P.
Kalinin, Alexei
Dalby, Stephen M.
Furman, Theodore R.
Flessner, Ryan
Rosario, Analisse
Zhao, Ralph
Roth, Megan
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 25 (08) : 1979 - 1987
[19] Integrating safety into technology commercialization for pilot plant scale-up
Boyd, Michael
Dever, John P.
Dombek, Duane
Bunning, Donald
Nunley, Mark
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[20] Scale-up and cost evaluation of a foamed emulsion bioreactor
Kan, E.
Deshusses, M. A.
ENVIRONMENTAL TECHNOLOGY, 2006, 27 (06) : 645 - 652

← 1 2 3 4 5 →