Scale-up and safety evaluation of a Sandmeyer reaction

被引：43
|
作者：
Nielsen, MA [1 ]
Nielsen, MK [1 ]
Pittelkow, A [1 ]
机构：
[1] H Lundbeck & Co AS, Chem Prod, DK-4500 Nykobing Sj, Denmark
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 06期
关键词：
D O I：
10.1021/op0498823
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A scale-up of a new process for the production of 2-chloro-5-trifluoromethyl-benzonitrile by a Sandmeyer reaction of 2-Chloro-5-trifluoromethylaniline with copper cyanide/sodium cyanide is described. To ensure a safe implementation, a safety evaluation of the process was carried out, which is described. in the following. The new process gives a better working environment and better productivity due to shorter reaction time.
引用
收藏
页码：1059 / 1064
页数：6
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