Cytotoxic clerodane diterpene esters from Laetia corymbulosa

被引:26
|
作者
Beutler, JA
McCall, KL
Herbert, K
Johnson, T
Shoemaker, RH
Boyd, MR [1 ]
机构
[1] NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA
[2] NCI, Frederick Canc Res & Dev Ctr, SAIC, Frederick, MD 21702 USA
关键词
Laetia corymbulosa; Flacourtiaceae; diterpenoids; corymbulosin A;
D O I
10.1016/S0031-9422(00)00281-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Three cytotoxic cleroodane diterpene esters, corymbulosins A-C, were isolated from an organic extract of the fruit of Laetia corymbulosa (Flacourtiaceae) from Peru. The structures were determined by spectroscopic methods as clerodane diterpenes unsaturated at C-3, C-13(16) and C-14. Corymbulosin A was esterified at C-2 with a decadienoate moiety, while corymbulosins B and C were C-2 epimers esterified at C-6 with a decanoate moiety. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:233 / 236
页数:4
相关论文
共 50 条
  • [21] Clerodane-type Diterpene Glycosides from Dicranopteris pedata
    Gao, Bei-Bei
    Ou, Yu-Fei
    Zhu, Qin-Feng
    Zhou, Zhi-Ping
    Deng, Zhen-Tao
    Li, Meng
    Zhao, Qin-Shi
    NATURAL PRODUCTS AND BIOPROSPECTING, 2021, 11 (05) : 557 - 564
  • [22] Clerodane-type Diterpene Glycosides from Dicranopteris pedata
    Bei-Bei Gao
    Yu-Fei Ou
    Qin-Feng Zhu
    Zhi-Ping Zhou
    Zhen-Tao Deng
    Meng Li
    Qin-Shi Zhao
    Natural Products and Bioprospecting, 2021, 11 : 557 - 564
  • [23] New Clerodane diterpene from the twigs of Casearia obliqua (Salicaceae)
    Vieira, G. M. J.
    Goncalves, T. O.
    Regasini, L. O.
    Ferreira, P. M. P.
    Lotufo, L. V.
    do O Pessoa, C.
    Bolzani, V. S.
    Cavalheiro, A. J.
    PLANTA MEDICA, 2008, 74 (09) : 1032 - 1032
  • [24] Three new clerodane diterpene derivatives from Casearia membranacea
    Shen, YC
    Cheng, YB
    Chen, YH
    Khalil, AT
    Ko, CL
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2005, 52 (06) : 1263 - 1268
  • [25] A new neo-clerodane diterpene from Aster souliei
    Wang, LM
    Guo, SJ
    Jia, ZJ
    Cheng, DL
    CHINESE CHEMICAL LETTERS, 1996, 7 (07) : 619 - 620
  • [26] A new neo-clerodane diterpene from Ajuga nipponensis
    Liu, Z
    Li, ZQ
    Zhang, CX
    Chen, RY
    Zhang, YG
    Qiu, YT
    Zhao, SH
    CHINESE CHEMICAL LETTERS, 1995, 6 (07) : 581 - 582
  • [27] NEW CLERODANE DITERPENE FROM TEUCRIUM-POLIUM L
    MARQUEZ, C
    VALVERDE, S
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1979, (10): : 2526 - 2527
  • [28] A NEW NEO-CLERODANE DITERPENE FROM ASTER SOULIEI
    Liang Ming WANG
    Shou Jun GUO
    Zhong Jian JIA and Dong Liang CHENG(Department of Chemistry
    ChineseChemicalLetters, 1996, (07) : 619 - 620
  • [29] A new clerodane diterpene with antifeedant activity from Teucrium tomentosum
    Devi, SS
    Malathi, R
    Rajan, SS
    Aravind, S
    Krishnakumari, GN
    Ravikumar, K
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2003, 59 : O530 - O532
  • [30] Crotomacrine, a new clerodane diterpene from the fruits of Croton macrostachyus
    Tane, P
    Tatsimo, S
    Connolly, JD
    TETRAHEDRON LETTERS, 2004, 45 (38) : 6997 - 6998