Cytotoxic clerodane diterpene esters from Laetia corymbulosa

被引：26
|
作者：
Beutler, JA
McCall, KL
Herbert, K
Johnson, T
Shoemaker, RH
Boyd, MR [1 ]
机构：
[1] NCI, Frederick Canc Res & Dev Ctr, Lab Drug Discovery Res & Dev, Frederick, MD 21702 USA
[2] NCI, Frederick Canc Res & Dev Ctr, SAIC, Frederick, MD 21702 USA
来源：
PHYTOCHEMISTRY | 2000年 / 55卷 / 03期
关键词：
Laetia corymbulosa; Flacourtiaceae; diterpenoids; corymbulosin A;
D O I：
10.1016/S0031-9422(00)00281-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three cytotoxic cleroodane diterpene esters, corymbulosins A-C, were isolated from an organic extract of the fruit of Laetia corymbulosa (Flacourtiaceae) from Peru. The structures were determined by spectroscopic methods as clerodane diterpenes unsaturated at C-3, C-13(16) and C-14. Corymbulosin A was esterified at C-2 with a decadienoate moiety, while corymbulosins B and C were C-2 epimers esterified at C-6 with a decanoate moiety. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：233 / 236
页数：4
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