The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

被引：95

作者：

Bandapalli, Obul R. ^{[1
,2
]}

Schuessele, Stephanie ^{[1
,2
]}

Kunz, Joachim B. ^{[1
,2
]}

Rausch, Tobias ^{[3
]}

Stutz, Adrian M. ^{[3
]}

Tal, Noa

Geron, Ifat ^{[4
,5
,6
,7
,8
]}

Gershman, Nava ^{[4
,5
,6
]}

Izraeli, Shai ^{[4
,5
,6
]}

Eilers, Juliane ^{[1
,2
]}

Vaezipour, Nina ^{[2
]}

Kirschner-Schwabe, Renate ^{[9
]}

Hof, Jana ^{[9
,10
]}

von Stackelberg, Arend ^{[9
]}

Schrappe, Martin ^{[11
]}

Stanulla, Martin ^{[11
,12
]}

Zimmermann, Martin ^{[12
]}

Koehler, Rolf ^{[13
]}

Avigad, Smadar ^{[14
]}

Handgretinger, Rupert ^{[15
]}

Frismantas, Viktoras ^{[16
]}

Bourquin, Jean Pierre ^{[16
]}

Bornhauser, Beat ^{[16
]}

Korbel, Jan O. ^{[3
]}

Muckenthaler, Martina U. ^{[1
,2
]}

Kulozik, Andreas E. ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Childrens Hosp, Dept Pediat Oncol Hematol & Immunol, D-69115 Heidelberg, Germany

[2] Heidelberg Univ, EMBL, Mol Med Partnership Unit, D-69115 Heidelberg, Germany

[3] EMBL, Genome Biol Unit, Heidelberg, Germany

[4] Sheba Med Ctr, Childhood Leukemia Res Inst, Tel Hashomer, Israel

[5] Sheba Med Ctr, Dept Pediat Hemato Oncol, Tel Hashomer, Israel

[6] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[7] Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA

[8] Univ Calif San Diego, Dept Med Stem Cell Program, San Diego, CA 92103 USA

[9] Charit Univ Med Berlin, Dept Pediat Oncol Hematol, Berlin, Germany

[10] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[11] Univ Hosp Schleswig Holstein, Campus Kiel, Germany

[12] Hannover Med Sch, Dept Pediat Hematol Oncol, Hannover, Germany

[13] Heidelberg Univ, Dept Human Genet, D-69115 Heidelberg, Germany

[14] Schneider Childrens Med Ctr Israel, Felsenstein Med Res Ctr & Pediat Hematol Oncol, Petah Tiqwa, Israel

[15] Univ Tubingen Hosp, Childrens Hosp, Tubingen, Germany

[16] Univ Childrens Hosp Zurich, Dept Oncol, Zurich, Switzerland

来源：

HAEMATOLOGICA | 2014年 / 99卷 / 10期

关键词：

STAT5B; mutation; pediatric T-ALL; OF-FUNCTION MUTATIONS; CONSTITUTIVE ACTIVATION; IL7R;

D O I：

10.3324/haematol.2014.104992

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E188 / E192

页数：5

共 32 条

[1] Rare occurrence of a STAT5B N642H mutation in adult T-cell acute lymphoblastic leukemia
Ma, Xiaolin
Wen, Lijun
Wu, Lili
Wang, Qingrong
Yao, Hong
Wang, Qian
Ma, Liang
Chen, Suning
CANCER GENETICS, 2015, 208 (1-2) : 52 - 53
[2] Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia
Cross, Nicholas C. P.
Hoade, Yvette
Tapper, William J.
Carreno-Tarragona, Gonzalo
Fanelli, Tiziana
Jawhar, Mohamad
Naumann, Nicole
Pieniak, Iwo
Luebke, Johannes
Ali, Sahra
Bhuller, Kaljit
Burgstaller, Sonja
Cargo, Catherine
Cavenagh, Jamie
Duncombe, Andrew S.
Das-Gupta, Emma
Evans, Paul
Forsyth, Peter
George, Philip
Grimley, Charlotte
Jack, Fergus
Munro, Laura
Mehra, Varun
Patel, Kavita
Rismani, Ali
Sciuccati, Gabriela
Thomas-Dewing, Rowena
Thornton, Patrick
Virchis, Andres
Watt, Simon
Wallis, Louise
Whiteway, Alastair
Zegocki, Kris
Bain, Barbara J.
Reiter, Andreas
Chase, Andrew
LEUKEMIA, 2019, 33 (02) : 415 - 425
[3] Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia
Nicholas C. P. Cross
Yvette Hoade
William J. Tapper
Gonzalo Carreno-Tarragona
Tiziana Fanelli
Mohamad Jawhar
Nicole Naumann
Iwo Pieniak
Johannes Lübke
Sahra Ali
Kaljit Bhuller
Sonja Burgstaller
Catherine Cargo
Jamie Cavenagh
Andrew S. Duncombe
Emma Das-Gupta
Paul Evans
Peter Forsyth
Philip George
Charlotte Grimley
Fergus Jack
Laura Munro
Varun Mehra
Kavita Patel
Ali Rismani
Gabriela Sciuccati
Rowena Thomas-Dewing
Patrick Thornton
Andres Virchis
Simon Watt
Louise Wallis
Alastair Whiteway
Kris Zegocki
Barbara J. Bain
Andreas Reiter
Andrew Chase
Leukemia, 2019, 33 : 415 - 425
[4] Clinicopathological Features of Hypereosinophilic Patients with An Activating STAT5B N642H Mutation
Cheng, Jinjun
Sun, Xiaoping
Klion, Amy
Maric, Irina
LABORATORY INVESTIGATION, 2021, 101 (SUPPL 1) : 813 - 814
[5] Clinicopathological Features of Hypereosinophilic Patients with An Activating STAT5B N642H Mutation
Cheng, Jinjun
Sun, Xiaoping
Klion, Amy
Maric, Irina
MODERN PATHOLOGY, 2021, 34 (SUPPL 2) : 813 - 814
[6] A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia
Ha Thi Thanh Pham
Hengstschlaeger, Markus
Moriggl, Richard
MOLECULAR & CELLULAR ONCOLOGY, 2018, 5 (03):
[7] A case of hypereosinophilic syndrome with STAT5b N642H mutation
Ding, Feihong
Wu, Chaoping
Li, Yun
Mukherjee, Sudipto
Ghosh, Subha
Arrossi, A. Valeria
Krishnan, Sudhir
OXFORD MEDICAL CASE REPORTS, 2021, (01): : 34 - 36
[8] Targeting STAT5B in T-cell acute lymphoblastic leukemia
Veloso, Alexandra
Cools, Jan
BLOOD, 2023, 142 (03) : 215 - 217
[9] Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
M Kontro
H Kuusanmäki
S Eldfors
T Burmeister
E I Andersson
Ø Bruserud
T H Brümmendorf
H Edgren
B T Gjertsen
M Itälä-Remes
S Lagström
O Lohi
T Lundán
J M L Martí
M M Majumder
A Parsons
T Pemovska
H Rajala
K Vettenranta
O Kallioniemi
S Mustjoki
K Porkka
C A Heckman
Leukemia, 2014, 28 : 1738 - 1742
[10] Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
Kontro, M.
Kuusanmaki, H.
Eldfors, S.
Burmeister, T.
Andersson, E. I.
Bruserud, O.
Bruemmendorf, T. H.
Edgren, H.
Gjertsen, B. T.
Itala-Remes, M.
Lagstrom, S.
Lohi, O.
Lundan, T.
Marti, J. M. L.
Majumder, M. M.
Parsons, A.
Pemovska, T.
Rajala, H.
Vettenranta, K.
Kallioniemi, O.
Mustjoki, S.
Porkka, K.
Heckman, C. A.
LEUKEMIA, 2014, 28 (08) : 1738 - 1742

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