The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse

被引：95

作者：

Bandapalli, Obul R. ^{[1
,2
]}

Schuessele, Stephanie ^{[1
,2
]}

Kunz, Joachim B. ^{[1
,2
]}

Rausch, Tobias ^{[3
]}

Stutz, Adrian M. ^{[3
]}

Tal, Noa

Geron, Ifat ^{[4
,5
,6
,7
,8
]}

Gershman, Nava ^{[4
,5
,6
]}

Izraeli, Shai ^{[4
,5
,6
]}

Eilers, Juliane ^{[1
,2
]}

Vaezipour, Nina ^{[2
]}

Kirschner-Schwabe, Renate ^{[9
]}

Hof, Jana ^{[9
,10
]}

von Stackelberg, Arend ^{[9
]}

Schrappe, Martin ^{[11
]}

Stanulla, Martin ^{[11
,12
]}

Zimmermann, Martin ^{[12
]}

Koehler, Rolf ^{[13
]}

Avigad, Smadar ^{[14
]}

Handgretinger, Rupert ^{[15
]}

Frismantas, Viktoras ^{[16
]}

Bourquin, Jean Pierre ^{[16
]}

Bornhauser, Beat ^{[16
]}

Korbel, Jan O. ^{[3
]}

Muckenthaler, Martina U. ^{[1
,2
]}

Kulozik, Andreas E. ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Childrens Hosp, Dept Pediat Oncol Hematol & Immunol, D-69115 Heidelberg, Germany

[2] Heidelberg Univ, EMBL, Mol Med Partnership Unit, D-69115 Heidelberg, Germany

[3] EMBL, Genome Biol Unit, Heidelberg, Germany

[4] Sheba Med Ctr, Childhood Leukemia Res Inst, Tel Hashomer, Israel

[5] Sheba Med Ctr, Dept Pediat Hemato Oncol, Tel Hashomer, Israel

[6] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[7] Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA

[8] Univ Calif San Diego, Dept Med Stem Cell Program, San Diego, CA 92103 USA

[9] Charit Univ Med Berlin, Dept Pediat Oncol Hematol, Berlin, Germany

[10] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[11] Univ Hosp Schleswig Holstein, Campus Kiel, Germany

[12] Hannover Med Sch, Dept Pediat Hematol Oncol, Hannover, Germany

[13] Heidelberg Univ, Dept Human Genet, D-69115 Heidelberg, Germany

[14] Schneider Childrens Med Ctr Israel, Felsenstein Med Res Ctr & Pediat Hematol Oncol, Petah Tiqwa, Israel

[15] Univ Tubingen Hosp, Childrens Hosp, Tubingen, Germany

[16] Univ Childrens Hosp Zurich, Dept Oncol, Zurich, Switzerland

来源：

HAEMATOLOGICA | 2014年 / 99卷 / 10期

关键词：

STAT5B; mutation; pediatric T-ALL; OF-FUNCTION MUTATIONS; CONSTITUTIVE ACTIVATION; IL7R;

D O I：

10.3324/haematol.2014.104992

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E188 / E192

页数：5

共 32 条

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[22] High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol
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[23] Impact of disease burden and late loss of B cell aplasia on the risk of relapse after CD19 chimeric antigen receptor T Cell (Tisagenlecleucel) infusion in pediatric and young adult patients with relapse/refractory acute lymphoblastic leukemia: role of B-cell monitoring
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[25] Oncogenetic Risk Classification Based on NOTCH1/FBXW7/RAS/PTEN Mutation Profiles Improves Outcome Prediction in Pediatric T-Cell Acute Lymphoblastic Leukemia, Treated According the Fralle 2000 T Guidelines
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[27] CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare chronic neutrophilic leukaemia manifested by rapidly progressive leucocytosis, severe infections, persistent fever and deep venous thrombosis
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[28] Impact of disease burden and late loss of B cell aplasia on the risk of relapse after CD19 chimeric antigen receptor T Cell (Tisagenlecleucel) infusion in pediatric and young adult patients with relapse/refractory acute lymphoblastic leukemia: role of B-cell monitoring (vol 14, 1280580, 2024)
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