A haunted beast: Targeting STAT5B(N642H) in T-Cell Neoplasia

被引：3
|
作者：
Ha Thi Thanh Pham [1 ,2 ,3 ]
Hengstschlaeger, Markus [3 ]
Moriggl, Richard [1 ,2 ,4 ]
机构：
[1] Ludwig Boltzmann Inst Canc Res, Vienna, Austria
[2] Univ Vet Med Vienna, Inst Anim Breeding & Genet, Vienna, Austria
[3] Med Univ Vienna, Inst Med Genet, Ctr Pathobiochem & Genet, Vienna, Austria
[4] Med Univ Vienna, Vienna, Austria
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 03期
基金：
奥地利科学基金会;
关键词：
Aurora kinase; JAK kinase; STAT5 (N642H) driver mutation; T-cell neoplasia;
D O I：
10.1080/23723556.2018.1435181
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The somatic hot spot mutation STAT5B(N642H) was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STATSB(N642H) expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
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页数：3
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