MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway

被引：41
|
作者：
Nong, Anna [1 ]
Li, Qingfeng [2 ]
Huang, Zhijing [3 ]
Xu, Yunan [1 ]
He, Kebin [1 ]
Jia, Yuying [1 ]
Cen, Zhenyi [1 ]
Liao, Lianghua [1 ]
Huang, Yueyan [2 ]
机构：
[1] Youjiang Med Univ Nationalities, Grad Sch, Baise, Guangxi, Peoples R China
[2] Youjiang Med Univ Nationalities, Dept Radiol, Affiliated Hosp, Baise, Guangxi, Peoples R China
[3] Youjiang Med Univ Nationalities, Dept Pediat Internal Med Ward 1, Affiliated Hosp, Baise 53300, Guangxi, Peoples R China
来源：
BIOENGINEERED | 2021年 / 12卷 / 01期
关键词：
Sepsis; blood-brain barrier; brain injury; miR-126; nf-kappa B signaling pathway; SEPSIS-ASSOCIATED ENCEPHALOPATHY; BARRIER DISRUPTION; INFLAMMATION; INHIBITION;
D O I：
10.1080/21655979.2021.1937905
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The purpose of this study was to investigate the impact and mechanism of microRNA miR-126 on brain injury induced by blood-brain barrier (BBB) damage in septic rats. We used cecal ligation and perforation (CLP) to create a rat model of sepsis. The experimental rats were randomly divided into Control group, CLP group, CLP + miR-NC group, CLP + miR-126 group and CLP + miR-126 + NF-kappa B pathway agonist (PMA) group. MiR-126 expressed in the brain tissue of CLP rats was down-regulated by qRT-PCR. Upregulation of miR-126 in CLP rats could improve brain injury and BBB marker protein level, reduce brain water content, Evans blue extravasation, inflammation, and excessive oxidative stress. This could also result in an inhibition of NF-kappa B signaling pathway activity. In conclusion, miR-126 overexpression can prevent brain injury caused by BBB damage via the inhibition of NF-kappa B signaling pathway activity. [GRAPHICS] .
引用
收藏
页码：2639 / 2648
页数：10
相关论文
共 50 条
  • [41] Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice
    Lei Zhao
    Haixiao Liu
    Liang Yue
    Jingbo Zhang
    Xia Li
    Bodong Wang
    Yan Lin
    Yan Qu
    Molecular Neurobiology, 2017, 54 : 1612 - 1621
  • [42] MicroRNA-23b attenuates the H2O2-induced injury of microglial cells via TAB3/NF-κB signaling pathway
    Zhou, Xin
    Chen, Jiajun
    Zhang, Hongjun
    Chen, Xiao
    Shao, Gaohai
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2018, 11 (12): : 5765 - 5773
  • [43] Syringaresinol attenuates osteoarthritis via regulating the NF-?B pathway
    Wang, Xianfeng
    Wang, Dangrang
    Deng, Biyong
    Yan, Litao
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 118
  • [44] Etomidate alleviates lung injury in sepsis rats through NF-κB signaling pathway
    Sun, S-F.
    Shao, X-Q.
    Xu, X-S.
    Wang, Y-Y.
    Lin, Y.
    Liu, F-Y.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2022, 36 (02): : 403 - 410
  • [45] Gastrodia elata specific miRNA attenuates neuroinflammation via modulating NF-κB signaling pathway
    Fu, Jianyuan
    Lu, Zhong-teng
    Wu, Guang
    Yang, Zhe-cheng
    Wu, Xiaoqi
    Wang, Dan
    Nie, Zuo-ming
    Sheng, Qing
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2024, 134 (12) : 1652 - 1662
  • [46] Mechanism of dexmedetomidine in brain injury of infant rats via the IRE1α/NF-κB/CHOP pathway
    Wang, Zhi
    Zhang, Lina
    Wu, Ting
    Pan, Xu
    Li, Le
    Yang, Xin
    Zhang, Miao
    Liu, Ying
    WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2025, 26 (02): : 103 - 115
  • [47] Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB/NLRP3 Signaling Pathway
    Tang, Yunliang
    Dong, Xiaoyang
    Chen, Gengfa
    Ye, Wen
    Kang, Junwei
    Tang, Yang
    Feng, Zhen
    NEUROREHABILITATION AND NEURAL REPAIR, 2020, 34 (09) : 831 - 843
  • [48] Upregulation of miR-126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway
    Su, Jianming
    Ding, Limin
    MOLECULAR MEDICINE REPORTS, 2021, 23 (05)
  • [49] Rolipram Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats: Possibly via Regulating the SIRT1/NF-κB Pathway
    Peng, Yucong
    Jin, Jianxiang
    Fan, Linfeng
    Xu, Hangzhe
    He, Pingyou
    Li, Jianru
    Chen, Ting
    Ruan, Wu
    Chen, Gao
    NEUROCHEMICAL RESEARCH, 2018, 43 (04) : 785 - 795
  • [50] Irisin alleviates renal injury caused by sepsis via the NF-κB signaling pathway
    Jin, Y-H
    Li, Z-Y
    Jiang, X-Q
    Wu, F.
    Li, Z-T
    Chen, H.
    Xi, D.
    Zhang, Y-Y
    Chen, Z-Q
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (11) : 6470 - 6476
12345