MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway

被引：41
|
作者：
Nong, Anna [1 ]
Li, Qingfeng [2 ]
Huang, Zhijing [3 ]
Xu, Yunan [1 ]
He, Kebin [1 ]
Jia, Yuying [1 ]
Cen, Zhenyi [1 ]
Liao, Lianghua [1 ]
Huang, Yueyan [2 ]
机构：
[1] Youjiang Med Univ Nationalities, Grad Sch, Baise, Guangxi, Peoples R China
[2] Youjiang Med Univ Nationalities, Dept Radiol, Affiliated Hosp, Baise, Guangxi, Peoples R China
[3] Youjiang Med Univ Nationalities, Dept Pediat Internal Med Ward 1, Affiliated Hosp, Baise 53300, Guangxi, Peoples R China
来源：
BIOENGINEERED | 2021年 / 12卷 / 01期
关键词：
Sepsis; blood-brain barrier; brain injury; miR-126; nf-kappa B signaling pathway; SEPSIS-ASSOCIATED ENCEPHALOPATHY; BARRIER DISRUPTION; INFLAMMATION; INHIBITION;
D O I：
10.1080/21655979.2021.1937905
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The purpose of this study was to investigate the impact and mechanism of microRNA miR-126 on brain injury induced by blood-brain barrier (BBB) damage in septic rats. We used cecal ligation and perforation (CLP) to create a rat model of sepsis. The experimental rats were randomly divided into Control group, CLP group, CLP + miR-NC group, CLP + miR-126 group and CLP + miR-126 + NF-kappa B pathway agonist (PMA) group. MiR-126 expressed in the brain tissue of CLP rats was down-regulated by qRT-PCR. Upregulation of miR-126 in CLP rats could improve brain injury and BBB marker protein level, reduce brain water content, Evans blue extravasation, inflammation, and excessive oxidative stress. This could also result in an inhibition of NF-kappa B signaling pathway activity. In conclusion, miR-126 overexpression can prevent brain injury caused by BBB damage via the inhibition of NF-kappa B signaling pathway activity. [GRAPHICS] .
引用
收藏
页码：2639 / 2648
页数：10
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