RNA gets in phase

被引：12
|
作者：
Saha, Shambaditya [1 ]
Hyman, Anthony A. [1 ]
机构：
[1] Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany
来源：
JOURNAL OF CELL BIOLOGY | 2017年 / 216卷 / 08期
关键词：
REPEAT; TRANSITIONS; EXPANSIONS; PROTEINS; FOCI;
D O I：
10.1083/jcb.201706034
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https ://doi. org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less gels, suggesting that RNA can scaffold the assembly of phase-separated compartments that sequester proteins/RNAs causing toxicity.
引用
收藏
页码：2235 / 2237
页数：3
相关论文
共 50 条
  • [31] The RNA face of phase separation
    Polymenidou, Magdalini
    SCIENCE, 2018, 360 (6391) : 859 - +
  • [32] Phase separation in RNA biology
    Lin, Yi
    Fang, Xiaofeng
    JOURNAL OF GENETICS AND GENOMICS, 2021, 48 (10) : 872 - 880
  • [33] Phase separation in RNA biology
    Yi Lin
    Xiaofeng Fang
    JournalofGeneticsandGenomics, 2021, 48 (10) : 872 - 880
  • [34] Getting RNA and Protein in Phase
    Weber, Stephanie C.
    Brangwynne, Clifford P.
    CELL, 2012, 149 (06) : 1188 - 1191
  • [35] ATHEROSCLEROSIS - WHO GETS IT AND HOW IT GETS THERE
    DUCAS, J
    CANADIAN JOURNAL OF CARDIOLOGY, 1993, 9 (02) : 160 - 161
  • [36] What gets measured gets done
    Water 21, 2006, APR. (45):
  • [37] What Gets Measured Gets Managed
    Lalji, Rahim
    Laguna, Javier Munoz
    Kauth, Jael
    Hofstetter, Leonie
    Kurmann, Astrid
    Adams, Jon
    Kongsted, Alice
    von Wyl, Viktor
    Puhan, Milo A.
    Hincapie, Cesar A.
    AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, 2024, 103 (09) : e113 - e121
  • [38] Plant design gets its details: Modulating plant architecture by phase transitions
    Gioppato, Helena Augusto
    Dornelas, Marcelo Carnier
    PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2021, 163 : 1 - 14
  • [39] What Gets Measured Gets (Micro)managed
    Ranji, Sumant R.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (17): : 1688 - 1689
  • [40] A STRUCTURAL PHASE-TRANSITION IN RNA
    FERNANDEZ, A
    BERICHTE DER BUNSEN-GESELLSCHAFT-PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 1989, 93 (05): : 574 - 575
12345