RNA gets in phase

被引：12
|
作者：
Saha, Shambaditya [1 ]
Hyman, Anthony A. [1 ]
机构：
[1] Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany
来源：
JOURNAL OF CELL BIOLOGY | 2017年 / 216卷 / 08期
关键词：
REPEAT; TRANSITIONS; EXPANSIONS; PROTEINS; FOCI;
D O I：
10.1083/jcb.201706034
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https ://doi. org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less gels, suggesting that RNA can scaffold the assembly of phase-separated compartments that sequester proteins/RNAs causing toxicity.
引用
收藏
页码：2235 / 2237
页数：3
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