SYNPHOS:: A new atropisomeric diphosphine ligand.: From laboratory-scale synthesis to scale-up development

被引：71
|
作者：
de Paule, SD
Jeulin, S
Ratovelomanana-Vidal, V
Genêt, JP
Champion, N
Deschaux, G
Dellis, P
机构：
[1] ENSCP, Lab Synthese Select Organ & Prod Nat, F-75231 Paris 05, France
[2] SYNKEM SAS, F-21301 Chenove, France
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 03期
关键词：
D O I：
10.1021/op034016w
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new optically active diphosphine ligand, [(5,6),(5',6')-bis(ethlenedioxy)biphenyl-2,2'-diyl]bis(diphenylphosphine) (SYNPHOS) has been synthesized. Laboratory-scale synthesis and scale-up development of this ligand are described herein. This new atropisomeric diphosphine was also used in ruthenium-catalyzed asymmetric hydrogenation.
引用
收藏
页码：399 / 406
页数：8
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