Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

被引：21
|
作者：
Jia, Xiangqian [1 ,2 ]
Wang, Weizhi [1 ]
Han, Qiuju [1 ,2 ]
Wang, Zihua [1 ]
Jia, Yunhong [2 ,3 ]
Hu, Zhiyuan [1 ]
机构：
[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[2] Liaoning Med Univ, Coll Pharm, Jinzhou 121001, Liaoning, Peoples R China
[3] Liaoning Med Univ, Coll Basic Sci, Jinzhou 121001, Liaoning, Peoples R China
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2016年 / 7卷 / 04期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
Nanocarrier; HER2; Antitumor; YLFFVFER; PEPTIDE; CANCER; NANOPARTICLES; RELEASE;
D O I：
10.1021/acsmedchemlett.6b00028
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.
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页码：429 / 434
页数：6
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