Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

被引：21
|
作者：
Jia, Xiangqian [1 ,2 ]
Wang, Weizhi [1 ]
Han, Qiuju [1 ,2 ]
Wang, Zihua [1 ]
Jia, Yunhong [2 ,3 ]
Hu, Zhiyuan [1 ]
机构：
[1] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
[2] Liaoning Med Univ, Coll Pharm, Jinzhou 121001, Liaoning, Peoples R China
[3] Liaoning Med Univ, Coll Basic Sci, Jinzhou 121001, Liaoning, Peoples R China
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2016年 / 7卷 / 04期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
Nanocarrier; HER2; Antitumor; YLFFVFER; PEPTIDE; CANCER; NANOPARTICLES; RELEASE;
D O I：
10.1021/acsmedchemlett.6b00028
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We present here a specific targeting nanocarrier system by functionalization of liposomes with one new type of breast cancer targeting peptide (H6, YLFFVFER) by a micromixer with high efficiency. Antitumor drugs could be successfully delivered into human epidermal growth factor receptor 2 (HER2) positive breast cancer cells with high efficiency in both in vivo and ex vivo models.
引用
收藏
页码：429 / 434
页数：6
相关论文
共 50 条
  • [21] Mucin-targeting-aptamer functionalized liposomes for delivery of cyclosporin A for dry eye diseases
    Wong, Ka-Ying
    Liu, Yibo
    Zhou, Liping
    Wong, Man-Sau
    Liu, Juewen
    JOURNAL OF MATERIALS CHEMISTRY B, 2023, 11 (21) : 4684 - 4694
  • [22] Preparation and the in-vivo evaluation of paclitaxel liposomes for lung targeting delivery in dogs
    Zhao, Ling
    Ye, Yun
    Li, Juan
    Wei, Yu-meng
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2011, 63 (01) : 80 - 86
  • [23] A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A
    Kozak, Andreja
    Mikhaylov, Georgy
    Khodakivskyi, Pavlo
    Goun, Elena
    Turk, Boris
    Vasiljeva, Olga
    PHARMACEUTICS, 2023, 15 (10)
  • [24] Nanoparticles and liposomes for drug targeting
    Fattal, E
    Alphandary, H
    Weingarten, C
    Vauthier, C
    Dubernet, C
    Andremont, A
    Couvreur, P
    FUTURE STRATEGIES FOR DRUG DELIVERY WITH PARTICULATE SYSTEMS, 1998, : 1 - 4
  • [25] Targeting antibodies dissociate from drug delivery liposomes during blood circulation
    Bjorgvinsdottir, Unnur J.
    Larsen, Jannik B.
    Bak, Martin
    Andresen, Thomas L.
    Munter, Rasmus
    JOURNAL OF CONTROLLED RELEASE, 2025, 379 : 982 - 992
  • [26] Double Peptide-Functionalized Carboxymethyl Chitosan-Coated Liposomes Loaded with Dexamethasone as a Potential Strategy for Active Targeting Drug Delivery
    Iftode, Loredana
    Cadinoiu, Anca Niculina
    Rata, Delia Mihaela
    Atanase, Leonard Ionut
    Vochita, Gabriela
    Radulescu, Luminita
    Popa, Marcel
    Gherghel, Daniela
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (03)
  • [27] Liposomes as drug delivery systems
    Clark, AP
    CANCER PRACTICE, 1998, 6 (04) : 251 - 253
  • [28] Liposomes - Opportunities in drug delivery
    Allen, TM
    DRUGS, 1997, 54 (Suppl 4) : 8 - 14
  • [29] LIPOSOMES FOR THE DRUG DELIVERY OF CARBORANES
    Olusanya, Temidayo
    NEURO-ONCOLOGY, 2013, 15 : 61 - 61
  • [30] Liposomes for drug delivery in stroke
    Bruch, Gisele E.
    Fernandes, Lorena F.
    Bassi, Beatriz L. T.
    Alves, Marco Tullio R.
    Pereira, Isabelle O.
    Frezard, Frederic
    Massensini, Andre R.
    BRAIN RESEARCH BULLETIN, 2019, 152 : 246 - 256
12345