First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

被引：33

作者：

Orlov, Nikolay V. ^{[1
]}

Ananikov, Valentine P. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 18期

关键词：

ABSOLUTE-CONFIGURATION; SECONDARY ALCOHOLS; P-31; NMR; O-METHYLMANDELATE; SIMPLE PROTOCOLS; SE-77; ASSIGNMENT; EXCESS; REAGENTS; ACID;

D O I：

10.1039/b923359h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(77)Se NMR offers superior sensing of chirality within the structure of the diastereomers (Delta delta up to 6.1 ppm), compared to (13)C (Delta delta < 1 ppm) and (1)H (Delta delta < 0.2 ppm). The developed procedure is equally well suitable for determination of the enantiomeric purity of chiral alcohols and amines as pure samples as well as reaction mixtures and crude products.

引用

页码：3212 / 3214

页数：3

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