First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy

被引：33
|
作者：
Orlov, Nikolay V. [1 ]
Ananikov, Valentine P. [1 ]
机构：
[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 18期
关键词：
ABSOLUTE-CONFIGURATION; SECONDARY ALCOHOLS; P-31; NMR; O-METHYLMANDELATE; SIMPLE PROTOCOLS; SE-77; ASSIGNMENT; EXCESS; REAGENTS; ACID;
D O I：
10.1039/b923359h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(77)Se NMR offers superior sensing of chirality within the structure of the diastereomers (Delta delta up to 6.1 ppm), compared to (13)C (Delta delta < 1 ppm) and (1)H (Delta delta < 0.2 ppm). The developed procedure is equally well suitable for determination of the enantiomeric purity of chiral alcohols and amines as pure samples as well as reaction mixtures and crude products.
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页码：3212 / 3214
页数：3
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