Bound Structure and Biochemical Mechanism of Action of BI 201335, a Potent, Non-covalent Inhibitor of HCV NS3-NS4A Protease

被引：2
|
作者：
Lemke, Christopher T. [1 ]
Zhao, Songping [1 ]
Goudreau, Nathalie [1 ]
Hucke, Oliver [1 ]
Thibeault, Diane [1 ]
Llinas-Brunet, Montse [1 ]
White, Peter W. [1 ]
机构：
[1] Boehringer Ingelheim Canada Ltd, Laval, PQ, Canada
来源：
ANTIVIRAL RESEARCH | 2010年 / 86卷 / 01期
关键词：
D O I：
10.1016/j.antiviral.2010.02.336
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
16
引用
收藏
页码：A20 / A21
页数：2
相关论文
共 50 条
  • [41] Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus
    Xu, Feng
    Kim, Jungchul
    Waldman, Jacob
    Wang, Tao
    Devine, Paul
    ORGANIC LETTERS, 2018, 20 (22) : 7261 - 7265
  • [42] A PHASE 1 STUDY TO EVALUATE THE INTERACTION OF HCV NS5B INHIBITOR MK-3682 WITH HCV NS3/4A PROTEASE INHIBITOR MK-5172 AND HCV NS5A INHIBITOR MK-8408 IN HEALTHY SUBJECTS
    Zhou, X. -J.
    Sicard, E.
    Chen, J.
    Frank, D.
    Gao, W.
    Rizk, M. L.
    Rhee, E. G.
    Butterton, J. R.
    Sullivan-Bolyai, J.
    JOURNAL OF HEPATOLOGY, 2015, 62 : S646 - S646
  • [43] Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
    Cummings, Maxwell D.
    Lindberg, Jimmy
    Lin, Tse-I
    de Kock, Herman
    Lenz, Oliver
    Lilja, Elisabet
    Fellander, Sara
    Baraznenok, Vera
    Nystrom, Susanne
    Nilsson, Magnus
    Vrang, Lotta
    Edlund, Michael
    Rosenquist, Asa
    Samuelsson, Bertil
    Raboisson, Pierre
    Simmen, Kenneth
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (09) : 1652 - 1655
  • [44] Structure-guided Discovery of a Novel Non-peptide Inhibitor of Dengue Virus NS2B-NS3 Protease
    Li, Linfeng
    Basavannacharya, Chandrakala
    Chan, Kitti Wing Ki
    Shang, Luqing
    Vasudevan, Subhash G.
    Yin, Zheng
    CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 86 (03) : 255 - 264
  • [45] IN VITRO COMBINATORY EFFECT OF HCV NS3/4A PROTEASE INHIBITOR ABT-450, NS5A INHIBITOR ABT-267, AND NON-NUCLEOSIDE NS5B POLYMERASE INHIBITOR ABT-333
    Pilot-Matias, T.
    Koev, G.
    Krishnan, P.
    Beyer, J.
    Reisch, T.
    Mondal, R.
    Lu, L.
    Middleton, T.
    Maring, C.
    Kati, W.
    Collins, C.
    Molla, A.
    JOURNAL OF HEPATOLOGY, 2012, 56 : S338 - S338
  • [46] NS3 peptide, a novel potent hepatitis C virus NS3 helicase inhibitor:: Its mechanism of action and antiviral activity in the replicon system
    Gozdek, Agnieszka
    Zhukov, Igor
    Polkowska, Agnieszka
    Poznanski, Jaroslaw
    Stankiewicz-Drogon, Anna
    Pawowicz, Jerzy M.
    Zagorski-Ostoja, Wodzirnierz
    Borowski, Peter
    Boguszewska-Chachulska, Anna M.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (02) : 393 - 401
  • [47] ACH-2684: HCV NS3 PROTEASE INHIBITOR WITH POTENT ACTIVITY AGAINST MULTIPLE GENOTYPES AND KNOWN RESISTANT VARIANTS
    Huang, Mingjun
    Podos, Steven
    Patel, Dharaben
    Yang, Guangwei
    Fabrycki, Joanne L.
    Zhao, Yongsen
    Marlor, Christopher
    Kapoor, Preeti
    Wang, Xiangzhu
    Hashimoto, Akihiro
    Gadhachanda, Venkat
    Pais, Godwin
    Chen, Dawei
    Agarwal, Atul
    Deshpande, Milind
    Stauber, Kathe L.
    Phadke, Avinash
    HEPATOLOGY, 2010, 52 (04) : 1204A - 1204A
  • [48] Furaprevir HCV NS3/4A protease inhibitor Treatment of chronic hepatitis C virus infection
    Ghosh, Prithwish
    Nehra, Vandana
    Temesgen, Zelalem
    DRUGS OF THE FUTURE, 2022, 47 (08) : 557 - 565
  • [49] Fragment-based design, synthesis, and binding of non-peptide mimics of NS4A and their binding to HCV NS3/4A protease
    El-Araby, Moustafa
    Omar, Abdelsattar
    Khayat, Maan
    Soror, Sameh
    Arold, Stefan
    El-Faky, Mahmoud
    Elalem, Elbatoul
    Bamane, Faida
    Asfour, Hany
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [50] Process development of ABT-450-A first generation NS3/4A protease inhibitor for HCV
    Caspi, Daniel D.
    Cink, Russell D.
    Clyne, Dean
    Diwan, Moiz
    Engstrom, Kenneth M.
    Grieme, Timothy
    Mei, Jianzhang
    Miller, Robert W.
    Mitchell, Clifford
    Napolitano, Jose G.
    Nere, Nandkishor
    Ravn, Matthew M.
    Sheikh, Ahmad
    Wagaw, Seble
    Zhang, Hongqiang
    TETRAHEDRON, 2019, 75 (32) : 4271 - 4286
12345