Bound Structure and Biochemical Mechanism of Action of BI 201335, a Potent, Non-covalent Inhibitor of HCV NS3-NS4A Protease

被引：2
|
作者：
Lemke, Christopher T. [1 ]
Zhao, Songping [1 ]
Goudreau, Nathalie [1 ]
Hucke, Oliver [1 ]
Thibeault, Diane [1 ]
Llinas-Brunet, Montse [1 ]
White, Peter W. [1 ]
机构：
[1] Boehringer Ingelheim Canada Ltd, Laval, PQ, Canada
来源：
ANTIVIRAL RESEARCH | 2010年 / 86卷 / 01期
关键词：
D O I：
10.1016/j.antiviral.2010.02.336
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
16
引用
收藏
页码：A20 / A21
页数：2
相关论文
共 50 条
  • [31] Phylogenetic analysis, structure modeling and docking study of HCV NS3 protease for the identification of potent inhibitors
    Zia, Asad
    Abbasi, Sumra Wajid
    Ahmad, Shabeer
    Zia, Muhammad
    Raza, Abida
    INFECTION GENETICS AND EVOLUTION, 2018, 59 : 51 - 62
  • [32] CHARACTERIZATION OF THE HEPATOSELECTIVE DISTRIBUTION OF ACH-1625, A POTENT, CLINICAL STAGE HCV NS3 PROTEASE INHIBITOR
    Stauber, K.
    Marlor, C. W.
    Mushtaq, G.
    Gadhachanda, V.
    Pais, G.
    Hashimoto, A.
    Phadke, A.
    Huang, M.
    Deshpande, M.
    JOURNAL OF HEPATOLOGY, 2010, 52 : S299 - S299
  • [33] QM/MM study of HCV NS3/NS4A protease with its main substrates: from the structure to the kinetics
    Martinez, J. A.
    Martinez, R.
    Puyuelo, M. P.
    Masgrau, L.
    Gonzalez, M.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2013, 42 : S196 - S196
  • [34] PRECLINICAL CHARACTERIZATION OF SCH 900518, A NOVEL MECHANISM-BASED INHIBITOR OF HCV NS3 PROTEASE
    Tong, X.
    Arasappan, A.
    Bennett, F.
    Chase, R.
    Feld, B.
    Guo, Z.
    Hart, A.
    Madison, V.
    Malcolm, B.
    Pichardo, J.
    Prongay, A.
    Ralston, R.
    Skelton, A.
    Xia, E.
    Njoroge, F. G.
    JOURNAL OF HEPATOLOGY, 2009, 50 : S351 - S351
  • [35] The metabolism and disposition of a potent inhibitor of hepatitis C virus NS3/4A protease
    Monteagudo, E.
    Fonsi, M.
    Chu, X.
    Bleasby, K.
    Evers, R.
    Pucci, V.
    Orsale, M. V.
    Cianetti, S.
    Ferrara, M.
    Harper, S.
    Laufer, R.
    Rowley, M.
    Summa, V.
    XENOBIOTICA, 2010, 40 (12) : 826 - 839
  • [36] Molecular mechanism susceptibility profile of BILN-2061 to various hepatitis C virus genotypes and NS3-NS4A protease inhibitor mutation: D168A and D168V.
    Courcambeck, J
    Perbost, R
    Chabaud, P
    Pepe, G
    Bouzidi, M
    Mabrouk, K
    Sabatier, JM
    Halfon, P
    HEPATOLOGY, 2004, 40 (04) : 385A - 385A
  • [37] MK-5172: A NOVEL HCV NS3/4A PROTEASE INHIBITOR WITH POTENT ACTIVITY AGAINST KNOWN RESISTANCE MUTANTS
    Carroll, S.
    McCauley, J.
    Ludmerer, S.
    Harper, S.
    Summa, V.
    Rowley, M.
    Rudd, M.
    Coleman, P.
    Liverton, N.
    Butcher, J.
    Mcintyre, C.
    Romano, J.
    Bush, K.
    Ferrara, M.
    Crescenzi, B.
    Petrocchi, A.
    Difilippo, M.
    Burlein, C.
    Dimuzio, J.
    Graham, D.
    Mchale, C.
    Stahlhut, M.
    Gates, A.
    Fandozzi, C.
    Trainor, N.
    Hazuda, D.
    Vacca, J.
    Olsen, D.
    JOURNAL OF HEPATOLOGY, 2010, 52 : S17 - S17
  • [38] GNS-227: A NEW POTENT AND SELECTIVE HCV NS3 PROTEASE INHIBITOR WITH A HIGH GENETIC BARRIER TO RESISTANCE
    Halfon, P.
    Courcambeck, J.
    Whitaker, T.
    Bouzidi, M.
    Mcbrayer, T. R.
    Roche, G.
    Tharnish, P. M.
    Pepe, G.
    Schinazi, R. F.
    Coats, S. J.
    JOURNAL OF HEPATOLOGY, 2011, 54 : S478 - S478
  • [39] Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor
    Rosenquist, Asa
    Samuelsson, Bertil
    Johansson, Per-Ola
    Cummings, Maxwell D.
    Lenz, Oliver
    Raboisson, Pierre
    Simmen, Kenny
    Vendeville, Sandrine
    de Kock, Herman
    Nilsson, Magnus
    Horvath, Andras
    Kalmeijer, Ronald
    de la Rosa, Guy
    Beumont-Mauviel, Maria
    JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (05) : 1673 - 1693
  • [40] Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA, replication and facilitates viral RNA clearance in replicon cells
    Lin, K
    Kwong, AD
    Lin, C
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (12) : 4784 - 4792
12345