Impurity Profile Study of Venlafaxine Hydrochloride, an Antipsychotic Drug Substance

被引：6

作者：

Saravanan, Mohanarangam ^{[1
,2
]}

Kumar, Karra Suresh ^{[1
]}

Reddy, Padi Pratap ^{[1
]}

Satyanarayana, Bollikonda ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Res & Dev, Integrated Prod Dev, Bachupalli, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Inst Sci & Technol, Hyderabad, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 13期

关键词：

Antipsychotic; depression; potential impurities; venlafaxine;

D O I：

10.1080/00397910903162767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Venlafaxine hydrochloride is a phenyl ethylamine derivative, used for the treatment of depression. During the process development of venlafaxine hydrochloride, six process-related potential impurities were detected in high-performance liquid chromatography. All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (IR, mass, 1H NMR, and 13C NMR) as described in this article.

引用

页码：1880 / 1886

页数：7

共 50 条

[41] The Degradation Chemistry of Prasugrel Hydrochloride: Part 1-Drug Substance
Baertschi, Steven W.
Maxwell-Backer, Lindsay
Clemens, Matthew
Smitka, Tim A.
Draper, Jerry R.
Taylor, K. Wayne
Kaerner, Andreas
Jansen, Patrick J.
JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 108 (09) : 2842 - 2857
[42] Challenges in the identification and quantification of an unknown impurity in chenodeoxycholic acid drug substance
Bouwhuis, Natalja
Polak, Yasmin
Schimmel, Anneliene M.
Bijleveld, Yuma A.
Giera, Martin A.
Heijink, Marieke
Vaz, Frederic M.
Bootsma, Albert H.
ten Berg-Lammers, Laureen A.
Swart, Noortje E. L.
Hollak, Carla E. M.
Jacobs, Bart A. W.
Kemper, E. Marleen
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2025, 205
[43] The isolation and identification of a toxic impurity in XP315 drug substance
Sigvardson, KW
Adams, SP
Barnes, TB
Blom, KF
Fortunak, JM
Haas, MJ
Reilly, KL
Repta, AJ
Nemeth, GA
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2002, 27 (1-2) : 327 - 334
[44] Impurity Profiling for a Scalable Continuous Synthesis and Crystallization of Carbamazepine Drug Substance
Glace, Matthew
Kraus, Harrison
Wu, Wei
Acevedo, David
Liu, Dongxia
Roper, Thomas D.
Mohammad, Adil
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2024, 28 (05) : 2013 - 2027
[45] Is it time to consider comorbid substance abuse as a new indication for antipsychotic drug development?
Awad, A. George
JOURNAL OF PSYCHOPHARMACOLOGY, 2012, 26 (07) : 953 - 957
[46] Implementation of QbD Approach to the Development of Chromatographic Methods for the Determination of Complete Impurity Profile of Substance on the Preclinical and Clinical Step of Drug Discovery Studies
Gurba-Bryskiewicz, Lidia
Dawid, Urszula
Smuga, Damian A.
Maruszak, Wioleta
Delis, Monika
Szymczak, Krzysztof
Stypik, Bartosz
Moroz, Aleksandra
Blocka, Aleksandra
Mroczkiewicz, Michal
Dubiel, Krzysztof
Wieczorek, Maciej
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (18)
[47] Complexation between venlafaxine hydrochloride and β-cyclodextrin:: Structural study by nuclear magnetic resonance spectroscopy
Ali, Syed Mashhood
Asmat, Fahmeena
Koketsu, Mamoru
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2006, 27 (09): : 1397 - 1400
[48] Simultaneous determination of the counter ion and possible impurity from the synthetic route in the pharmaceutical substance prasugrel hydrochloride
Maruszak, Wioleta
Cybulski, Marcin
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 105 : 32 - 38
[49] Identification, isolation and characterization of potential degradation products in pioglitazone hydrochloride drug substance
Ramulu, K.
Kumar, T. Thilak
Krishna, S. Radha
Vasudev, R.
Kaviraj, M.
Rao, B. M.
Rao, N. Someswara
PHARMAZIE, 2010, 65 (03): : 162 - 168
[50] AN ELECTROENCEPHALOGRAPHICAL STUDY ON TIMIPERONE, A NEW ANTIPSYCHOTIC DRUG
TANAKA, M
KOJIMA, H
AKASHI, A
FOLIA PHARMACOLOGICA JAPONICA, 1984, 84 (02) : 213 - 219

← 1 2 3 4 5 →