Impurity Profile Study of Venlafaxine Hydrochloride, an Antipsychotic Drug Substance

被引：6

作者：

Saravanan, Mohanarangam ^{[1
,2
]}

Kumar, Karra Suresh ^{[1
]}

Reddy, Padi Pratap ^{[1
]}

Satyanarayana, Bollikonda ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Res & Dev, Integrated Prod Dev, Bachupalli, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Inst Sci & Technol, Hyderabad, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 13期

关键词：

Antipsychotic; depression; potential impurities; venlafaxine;

D O I：

10.1080/00397910903162767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Venlafaxine hydrochloride is a phenyl ethylamine derivative, used for the treatment of depression. During the process development of venlafaxine hydrochloride, six process-related potential impurities were detected in high-performance liquid chromatography. All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (IR, mass, 1H NMR, and 13C NMR) as described in this article.

引用

页码：1880 / 1886

页数：7

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