Impurity Profile Study of Venlafaxine Hydrochloride, an Antipsychotic Drug Substance

被引：6

作者：

Saravanan, Mohanarangam ^{[1
,2
]}

Kumar, Karra Suresh ^{[1
]}

Reddy, Padi Pratap ^{[1
]}

Satyanarayana, Bollikonda ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Res & Dev, Integrated Prod Dev, Bachupalli, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Inst Sci & Technol, Hyderabad, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2010年 / 40卷 / 13期

关键词：

Antipsychotic; depression; potential impurities; venlafaxine;

D O I：

10.1080/00397910903162767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Venlafaxine hydrochloride is a phenyl ethylamine derivative, used for the treatment of depression. During the process development of venlafaxine hydrochloride, six process-related potential impurities were detected in high-performance liquid chromatography. All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (IR, mass, 1H NMR, and 13C NMR) as described in this article.

引用

页码：1880 / 1886

页数：7

共 50 条

[1] Identification and Characterization of New Impurity in Phenoxybenzamine Hydrochloride Drug Substance
Guduri, A. K.
Bonige, K. B.
Vundavilli, J. K.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2024, 94 (07) : 1768 - 1775
[2] Study of impurity carryover and impurity profile in Febuxostat drug substance by LC-MS/MS technique
Kadivar, Mustakhusen H.
Sinha, Praveen Kumar
Kushwah, Dharmendra
Jana, Pijush
Sharma, Hitesh
Bapodra, Atul
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2011, 56 (04) : 749 - 757
[3] Impurity profile study of lopinavir and validation of HPLC method for the determination of related substances in lopinavir drug substance
Chitturi, Sreenivasa Rao
Bharathi, Ch.
Reddy, A. V. Raghava
Reddy, K. Chandrasekhar
Sharma, Hemant Kumar
Handa, Vijay Kumar
Dandala, Ramesh
Bindu, V. Hima
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2008, 48 (05) : 1430 - 1440
[4] Lipid profile in antipsychotic drug users: A comparative study
Roohafza, Hamidreza
Khani, Azam
Afshar, Hamid
Garakyaraghi, Mohammad
Amirpour, Afshin
Ghodsi, Basir
ARYA ATHEROSCLEROSIS, 2013, 9 (03) : 198 - 202
[5] HPTLC Analysis of Venlafaxine Hydrochloride in the Bulk Drug and Tablets
Vimal D. Shirvi
Kupsad P. Channabasavaraj
G. Vijaya Kumar
T. Tamizh Mani
JPC – Journal of Planar Chromatography – Modern TLC, 2010, 23 : 369 - 372
[6] HPTLC Analysis of Venlafaxine Hydrochloride in the Bulk Drug and Tablets
Shirvi, Vimal D.
Channabasavaraj, Kupsad P.
Kumar, G. Vijaya
Mani, T. Tamizh
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, 2010, 23 (05) : 369 - 372
[7] An Improved and Impurity-Free Large-Scale Synthesis of Venlafaxine Hydrochloride
Saravanan, Mohanarangam
Satyanarayana, Bollikonda
Reddy, Padi Pratap
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2011, 15 (06) : 1392 - 1395
[8] Synthesis and characterization of impurity G of risperidone: An antipsychotic drug
Janardhana Rao, R., 1600, Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India (05):
[9] Synergistic effect of an antipsychotic drug chlorpromazine hydrochloride with pluronic triblock copolymer: A physicochemical study
Azum, Naved
Rub, Malik Abdul
Asiri, Abdullah M.
Kashmery, Heba Abbas
JOURNAL OF MOLECULAR LIQUIDS, 2018, 260 : 159 - 165
[10] Identification of an isomer impurity in piperaquine drug substance
Lindegardh, N.
Giorgi, F.
Gailetti, B.
Di Mattia, M.
Quaglia, M.
Carnevale, D.
White, N. J.
Mazzanti, A.
Day, N. P. J.
JOURNAL OF CHROMATOGRAPHY A, 2006, 1135 (02) : 166 - 169

← 1 2 3 4 5 →