Biochemical mechanisms of the RNA-induced silencing complex

被引：37

作者：

Paroo, Zain

Liu, Qinghua

Wang, Xiaodong

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA

来源：

CELL RESEARCH | 2007年 / 17卷 / 03期

关键词：

argonaute; Dicer; dsRBP; RISC; RNA interference; DOUBLE-STRANDED-RNA; MICRORNA-DEPENDENT LOCALIZATION; TARGETED MESSENGER-RNAS; C-ELEGANS; ENZYME COMPLEX; CAENORHABDITIS-ELEGANS; CRYSTAL-STRUCTURE; MAMMALIAN-CELLS; DISTINCT ROLES; HUMAN RISC;

D O I：

10.1038/sj.cr.7310148

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In less than 10 years since its inception, RNA interference (RNAi) has had extraordinary impact on biomedical science. RNAI has been demonstrated to influence numerous biological and disease pathways. Development and adoption of RNAI technologies have been prolific ranging from basic loss-of-function tools, genome-wide screening libraries to pharmaceutical target validation and therapeutic development. However, understanding of the molecular mechanisms of RNAi is far from complete. The purpose of this brief review is to highlight key achievements in elucidating the biochemical mechanisms of the RNA-induced silencing complex and to outline major challenges for the field.

引用

页码：187 / 194

页数：8

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